Central control of feeding behavior by neuropeptide Y.
Central control of feeding behavior by neuropeptide Y.
复制标题
神经肽 Y 对摄食行为的中枢控制。
DOI：
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发表时间：
1998
影响因子：
3.1
通讯作者：
G. Poindexter
中科院分区：
文献类型：
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作者：
I. Zimanyi;Z. Fathi;G. Poindexter
肥胖在西方社会是一个严重的健康问题，因此它的治疗已成为科学界强烈兴趣的主题。最近大量的出版物列举了不同的中枢和外周因素，这些因素在调节食物摄入、体重和能量消耗方面发挥着重要作用。神经肽Y是一种36个氨基酸的肽，在大脑中非常丰富，似乎是这些调节中更重要的参与者之一。最近已经克隆了五种NPY受体，药理学证据强烈支持第六种受体的存在。关于哪种NPY受体介导NPY对食物摄取的影响，有许多相互矛盾的发现。本文将综述神经肽Y在调节食物摄入和能量消耗方面的作用，并讨论神经肽Y受体介导这种作用的药理学和分子证据。本文还将综述近年来在设计新型的神经肽Y配体，特别是神经肽Y受体拮抗剂，以治疗肥胖症方面所取得的进展。
Obesity is a serious health problem in the Western societies, therefore its treatment has become the subject of intense interest in the scientific community. A significant number of recent publications enlist different central and peripheral factors which play important roles in the regulation of food intake, body weight and energy expenditure. Neuropeptide Y, a 36 amino acid peptide, which is quite abundant in the brain, seems to be one of the more important players in these regulations. Recently five NPY receptors have been cloned and pharmacological evidence strongly supports the existence of a sixth receptor. There are many contradictory findings regarding which NPY receptor mediates the effect of NPY on food intake. This article will review the effects of NPY on the regulation of food intake and energy expenditure and will discuss the pharmacological and molecular evidence as to which NPY receptor(s) mediate this effect. The review will also summarize the progress which has been made in the design of novel NPY-ergic ligands, especially NPY receptor antagonists, for potential use in the treatment of obesity.