Mannheim intima-media thickness consensus
Mannheim intima-media thickness consensus
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DOI：
10.1159/000081812
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发表时间：
2004-01-01
影响因子：
2.9
通讯作者：
Zannad, F
中科院分区：
文献类型：
--
作者：
Touboul, PJ;Hennerici, G;Zannad, F
动脉内膜-中层厚度(IMT)在临床试验中越来越多地被用作决定降低动脉粥样硬化危险因素的干预措施成功与否的替代终点。统一标准来区分早期动脉粥样硬化斑块形成和IMT增厚以及标准化IMT测量的必要性在这份共识声明中被提及。斑块被定义为侵袭动脉管腔至少0.5 mm或周围IMT值的50%或显示从中膜-外膜界面到内膜界面厚度大于或等于1.5 mm的局灶性结构。建议在所有涉及血管疾病的流行病学和干预性试验中使用标准的IMT测量，以改善调查人群的特征。共识的结论是，除了少数例外，没有必要‘治疗IMT值’，也没有必要监测个别患者的IMT值。尽管IMT被认为是一种重要的危险标记物，但它不能满足公认的危险因素的特征。本共识声明中建议的标准化方法将促进同质化的数据收集和分析。这将有助于提高纳入IMT测量的研究的能力，并促进用于荟萃分析的大型数据库的合并。版权所有(C)2004 S.Karger AG，巴塞尔。
Intima-media thickness (IMT) is increasingly used in clinical trials as a surrogate end point for determining the success of interventions that lower risk factors for atherosclerosis. The necessity for unified criteria to distinguish early atherosclerotic plaque formation from thickening of IMT and to standardize IMT measurements is addressed in this consensus statement. Plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness of greater than or equal to1.5 mm as measured from the media-adventitia interface to the intimalumen interface. Standard use of IMT measurements is recommended in all epidemiological and interventional trials dealing with vascular diseases to improve characterization of the population investigated. The consensus concludes that there is no need to 'treat IMT values' nor to monitor IMT values in individual patients apart from few exceptions. Although IMT has been suggested to represent an important risk marker, it does not fulfill the characteristics of an accepted risk factor. Standardized methods recommended in this consensus statement will foster homogenous data collection and analysis. This will help to improve the power of studies incorporating IMT measurements and to facilitate the merging of large databases for meta- analyses. Copyright (C) 2004 S. Karger AG, Basel.