Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.
Dietary and nutrition interventions for the therapeutic treatment of chronic fatigue syndrome/myalgic encephalomyelitis: a systematic review.
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DOI：
10.1111/jhn.12435
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Marshall-Gradisnik S
中科院分区：
文献类型：
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作者：
Campagnolo N;Johnston S;Collatz A;Staines D;Marshall-Gradisnik S
慢性疲劳综合征/肌痛性脑脊髓炎（CFS/ME）的特征是不明原因的疲劳至少6个月，伴随着一系列不同但一致的症状。饮食调整和营养补充剂可用于改善患者的结局，如疲劳和生活质量。我们回顾并讨论了可能有助于缓解CFS/ME症状的营养干预措施的证据。Medline、Cinahl和Scopus从1994年至2016年5月进行了系统检索。纳入了所有营养干预研究，其中CFS/ME患者根据以患者为中心的结局（疲劳、生活质量、体力活动和/或心理健康）改变了饮食或补充了习惯性饮食。纳入了17项符合纳入标准的研究。其中，对14种不同的干预措施进行了研究。许多研究没有显示对CFS/ME的治疗益处。观察到烟酰胺腺嘌呤二核苷酸氢化物（NADH）、益生菌、富含可可多酚的巧克力以及NADH和辅酶Q10的组合改善疲劳。这项审查确定了使用营养补充剂和消除或修改饮食来缓解CFS/ME症状的证据不足。研究受到调查干预措施的研究数量、小样本量、研究持续时间、使用的仪器种类以及未报告饮食摄入方法的研究的限制。进一步的研究是必要的同质CFS/ME人群。
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is characterised by unexplained fatigue for at least 6 months accompanied by a diverse but consistent set of symptoms. Diet modification and nutritional supplements could be used to improve patient outcomes, such fatigue and quality of life. We reviewed and discussed the evidence for nutritional interventions that may assist in alleviating symptoms of CFS/ME. Medline, Cinahl and Scopus were systematically searched from 1994 to May 2016. All studies on nutrition intervention were included where CFS/ME patients modified their diet or supplemented their habitual diet on patient‐centred outcomes (fatigue, quality of life, physical activity and/or psychological wellbeing). Seventeen studies were included that meet the inclusion criteria. Of these, 14 different interventions were investigated on study outcomes. Many studies did not show therapeutic benefit on CFS/ME. Improvements in fatigue were observed for nicotinamide adenine dinucleotide hydride (NADH), probiotics, high cocoa polyphenol rich chocolate, and a combination of NADH and coenzyme Q10. This review identified insufficient evidence for the use of nutritional supplements and elimination or modified diets to relieve CFS/ME symptoms. Studies were limited by the number of studies investigating the interventions, small sample sizes, study duration, variety of instruments used, and studies not reporting dietary intake method. Further research is warranted in homogeneous CFS/ME populations.