A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic α-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust
A one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic α-amino acid derivatives activated by the combination of iodobenzene diacetate/iodine and iron dust
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DOI：
10.1039/b815227f
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Wang, Bing
中科院分区：
文献类型：
--
作者：
Fan, Renhua;Li, Weixun;Wang, Bing
报道了无环α-氨基酸衍生物与富电子芳香族化合物的一锅氧化脱羧-Friedel-Crafts反应。该反应是由二乙酸碘苯、碘和铁粉共同活化的，反应体系温和、简单。铁的使用避免了芳香族化合物的氧化，并且原位生成Fe（III）盐以促进傅-克反应避免了使用高度吸湿性的FeCl 3。
An efficient one-pot oxidative decarboxylation-Friedel-Crafts reaction of acyclic alpha-amino acid derivatives with electron-rich aromatic compounds is reported. The reaction is activated by the combination of iodobenzene diacetate, iodine and iron dust, resulting in a mild and simple reaction system. The use of iron avoids the oxidation of aromatic compounds, and in situ generation of Fe(III) salts to promote the Friedel-Crafts reaction avoids the use of the highly hygroscopic FeCl3.