Class II virus membrane fusion proteins
Class II virus membrane fusion proteins
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DOI：
10.1016/j.virol.2005.09.036
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发表时间：
2006-01-05
期刊：
影响因子：
3.7
通讯作者：
Kielian, M
中科院分区：
文献类型：
--
作者：
Kielian, M
有包膜的动物病毒将其膜与宿主细胞膜融合，从而将病毒遗传物质递送到细胞质中并启动感染。这一关键的膜融合反应由称为融合蛋白的病毒跨膜蛋白介导，该蛋白将其疏水性融合肽插入细胞膜并重新折叠以驱动融合反应。本文综述了甲病毒和黄病毒11类融合蛋白的结构和功能的研究进展。融合蛋白的重折叠反应的抑制证实了其在融合中的重要性，并为这些医学上重要的病毒提出了新的抗病毒策略。(c)2005年爱思唯尔公司All rights reserved.
Enveloped animal viruses fuse their membrane with a host cell membrane, thus delivering the virus genetic material into the cytoplasm and initiating infection. This critical membrane fusion reaction is mediated by a virus transmembrane protein known as the fusion protein, which inserts its hydrophobic fusion peptide into the cell membrane and refolds to drive the fusion reaction. This review describes recent advances in our understanding of the structure and function of the class 11 fusion proteins of the alphaviruses and flaviviruses. Inhibition of the fusion protein refolding reaction confirms its importance in fusion and suggests new antiviral strategies for these medically important viruses. (c) 2005 Elsevier Inc. All rights reserved.