Pituitary Function and IGF-I Levels following Ischemic Stroke
Pituitary Function and IGF-I Levels following Ischemic Stroke
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DOI：
10.1159/000321738
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Sitzer, Matthias
中科院分区：
文献类型：
--
作者：
Boehncke, Sandra;Ackermann, Hanns;Sitzer, Matthias
背景资料：垂体功能障碍是创伤性脑损伤和蛛网膜下腔出血的一种已知并发症，但关于垂体功能障碍作为缺血性卒中并发症的数据很少。研究方法：我们前瞻性研究了缺血性卒中后66-274天的患者，评估垂体功能障碍的患病率（通过联合释放激素测试：GHRH，CRH），卒中严重程度，焦虑和抑郁的结局和发生率。结果如下：32例患者（82%）出现一定程度的垂体功能障碍，主要是生长激素反应受损（79.5%）和继发性肾上腺功能衰竭（14.6%）。28.3%和32.7%的患者存在异常焦虑和/或抑郁。NIHSS（美国国立卫生研究院卒中量表）介于1和15之间。神经功能缺损改善（Delta NIHSS）与基线NIHSS显著相关（p < 0.001），但与垂体功能无关。结论：缺血性卒中患者可能患有垂体功能障碍，主要是生长激素反应受损和继发性肾上腺功能衰竭。我们建议中风患者应进行垂体检测。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Pituitary dysfunction is a known complication of traumatic brain injury and subarachnoidal hemorrhage but there are few data about pituitary dysfunction as a complication of ischemic stroke. Methods: We prospectively studied patients 66-274 days after an ischemic stroke, evaluating the prevalence of pituitary dysfunction (by combined releasing hormone testing: GHRH, CRH), stroke severity, outcome and incidence of anxiety and depression. Results: Thirty-two patients (82%) presented with some degree of pituitary dysfunction with predominantly impaired growth hormone response (79.5%) and secondary adrenal failure (14.6%). Abnormal anxiety and/or depression was found in 28.3 and 32.7% of the patients. NIHSS (National Institute of Health Stroke Scale) varied between 1 and 15. Improvement in neurological deficit (Delta NIHSS) correlated significantly with NIHSS at baseline (p < 0.001) but not with pituitary function. Conclusions: Patients with ischemic stroke may suffer from pituitary dysfunction with predominantly impaired growth hormone response and secondary adrenal failure. We suggest that patients who suffer from stroke should undergo pituitary testing. Copyright (C) 2010 S. Karger AG, Basel