Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
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DOI：
10.1016/j.jconrel.2003.12.022
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发表时间：
2004-03-24
影响因子：
10.8
通讯作者：
Lowman, AM
中科院分区：
文献类型：
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作者：
Nakamura, K;Murray, RJ;Lowman, AM
采用不同的反应水含量制备了聚（甲基丙烯酸-g-乙二醇）水凝胶，以改变其网络尺寸、溶胀行为和胰岛素负载/释放动力学。用更大的反应溶剂含量制备的凝胶溶胀到更大的程度并且具有更大的网络筛目尺寸。所有的水凝胶都能够结合胰岛素，并保护其在酸性介质中不释放。在较高的pH（7.4）下，释放速率随反应溶剂含量的增加而增加。使用闭环动物模型，所有胰岛素负载制剂在小肠上部产生显著的胰岛素吸收，并具有降血糖作用。在这些研究中，生物利用度范围为4.6%-7.2%，取决于反应溶剂含量。(C)2004 Elsevier B. V.保留所有权利。
Hydrogels of poly(methacrylic acid-g-ethylene glycol) were prepared using different reaction water contents in order to vary the network mesh size, swelling behavior and insulin loading/release kinetics. Gels prepared with greater reaction solvent contents swelled to a greater degree and had a larger network mesh size. All of the hydrogels were able to incorporate insulin and protected it from release in acidic media. At higher pH (7.4), the release rates increased with reaction solvent content. Using a closed loop animal model, all of the insulin loaded formulations produced significant insulin absorption in the upper small intestine combined with hypoglycemic effects. In these studies, bioavailabilities ranged from 4.6% to 7.2% and were dependent on reaction solvent content. (C) 2004 Elsevier B.V. All rights reserved.