TOPOLOGY AND DIMENSIONS OF PIG CORONARY CAPILLARY NETWORK
TOPOLOGY AND DIMENSIONS OF PIG CORONARY CAPILLARY NETWORK
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DOI：
10.1152/ajpheart.1994.267.1.h319
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发表时间：
1994-07-01
影响因子：
--
通讯作者：
FUNG, YCB
中科院分区：
文献类型：
--
作者：
KASSAB, GS;FUNG, YCB
为了为冠状脉管系统的任何数学模型提供形态测量基础，提供了冠状毛细血管网络的数据以及相对于毛细血管的小动脉供应和小静脉引流的拓扑结构。测量了四只猪左右心室冠状毛细血管的直径、长度和分支模式。确定了冠状动脉和小静脉的位置，构建了拓扑图，并测量了连接小动脉和相邻小静脉的毛细血管的平均功能长度。通过用催化聚合物灌注冠状血管来固定脉管系统。聚合物硬化后，取出心肌栓塞、切片、脱水并透明，使毛细血管网络在光学显微镜下可见。然后通过光学切片追踪毛细血管。我们将毛细血管指定为零阶血管；我们进一步将毛细血管指定为直接由小动脉供血的毛细血管（C-0a）、直接引流到小静脉的毛细血管（C-0v）以及连接到C-0a和C-0v的毛细血管。毛细血管以Y、T、H或发夹形式连接，并通过毛细血管交叉连接（C-cc）进行吻合。 C-cc血管可以连接相邻的毛细血管或源自不同小动脉的毛细血管。毛细血管、动脉和静脉之间的连接以连接矩阵的形式呈现。结合目前的数据和动脉、静脉树的数据，我们得到了猪心脏所有血管的完整统计数据。这样的数据集将作为冠状动脉血流动力学的基础。
To provide a morphometric basis for any mathematical modeling of the coronary vasculature, data on the network of coronary capillary blood vessels and the topology of the arteriolar supply and venular drainage relative to the capillaries are presented. The diameters, lengths, and branching patterns of the coronary capillary blood vessels in the right and left ventricles of four pigs were measured. The locations of the coronary arterioles and venules were identified, topological maps were constructed, and the mean functional length of capillaries connecting an arteriole to an adjacent venule was measured. The vasculature was fixed by perfusing the coronary vessels with a catalyzed polymer. After the polymer hardened, plugs of the myocardium were removed, sectioned, dehydrated, and cleared to render the capillary network visible in a light microscope. The capillaries then were traced by optical sectioning. We designated the capillaries as blood vessels of order number zero; we further designated the capillaries as those fed directly by arterioles (C-0a), those drained directly into venules (C-0v), and those capillary vessels connected to C-0a and C-0v, The capillaries are connected in patterns identified as Y, T, H, or hairpin and anastomosed through capillary cross-connections (C-cc). The C-cc vessels may connect adjacent capillaries or capillaries originating from different arterioles. The connection among the capillaries, arteries, and veins is presented in terms of a connectivity matrix. Combining the present data with those for the arterial and venous trees, we have obtained a complete set of statistical data of all the blood vessels of the heart of the pig. Such a data set will serve as the basis of coronary hemodynamics.