Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome.
Happiness and stress alter susceptibility to cardiac events in Long QT Syndrome.
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快乐和压力会改变长 QT 综合征患者对心脏事件的易感性。
DOI：
10.1111/j.1542-474x.2009.00295.x
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Moss,ArthurJ
中科院分区：
文献类型：
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作者：
Lane,RichardD;Reis,HarryT;Peterson,DerickR;Zareba,Wojciech;Moss,ArthurJ
目的：我们试图确定长 QT 综合征 (LQTS) 患者发生心律失常事件之前的情况是否与之前控制事件之前的情况不同，LQTS 是一种特征明确的遗传性疾病，使受影响的个体面临心源性猝死的风险。方法：38 名 LQTS 患者（89% 女性）完成了“病例交叉访谈”，其中每位患者通过报告心律失常事件之前的情况作为自己的对照（晕厥、心脏骤停中止或除颤器放电）和控制时间之前（倒数第二个生日）。调查平均在心脏事件和控制事件发生后 17 个月进行。 结果：在心脏事件发生前 24 小时内，与控制事件发生前一天相比，心理压力升高，幸福峰值降低，劳累峰值没有显着差异。对事件和对照事件之前的 6 个月间隔进行评估，这三个变量均与事件没有显着相关性。 结论：幸福感与 LQTS 患者 24 小时心脏事件风险降低相关，而压力则具有相反的作用。据我们所知，这是第一份表明积极情绪可能对危及生命的室性心律失常具有保护作用的报告。这项研究进一步支持了情绪在影响心律失常患者心脏事件中的作用。
Objective:We sought to determine whether the circumstances preceding an arrhythmic event differed from those preceding a prior control occasion in patients with Long QT Syndrome (LQTS), a well‐characterized genetic disorder that puts affected individuals at risk for sudden cardiac death.Methods:Thirty‐eight patients (89% female) with LQTS completed a “case‐crossover interview” in which each patient served as his/her own control by reporting on circumstances preceding an arrhythmic event (syncope, aborted cardiac arrest, or defibrillator discharge) and preceding a control occasion (the next‐to‐last birthday). On average the interview was conducted 17 months after the cardiac event and control occasion.Results:During the 24‐hour period preceding the cardiac event compared to the day before the control occasion, psychological stress was elevated, peak happiness was reduced, and peak exertion was not significantly different. Rated for the 6‐month intervals preceding the event and control occasions, none of these three variables was significantly associated with events.Conclusions:Happiness is associated with a reduction in the 24‐hour risk of cardiac events in patients with LQTS, with stress having an opposite effect. To our knowledge, this is the first report indicating that positive emotion may have a protective effect on life‐threatening ventricular arrhythmias. This study lends further support to the role of emotions in influencing cardiac events in arrhythmia‐prone patients.