SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA
SAR and molecular mechanism study of novel acylhydrazone compounds targeting HIV-1 CA
复制标题
DOI：
10.1016/j.bmc.2010.02.003
复制
发表时间：
2010-03-15
影响因子：
3.5
通讯作者：
Yang, Ming
中科院分区：
文献类型：
--
作者：
Jin, Yinxue;Tan, Zhiwu;Yang, Ming
我们合成了一系列带有天然氨基酸侧链的酰腙化合物作为 HIV 组装抑制剂。生物学评价表明该化合物具有抗SIV和衣壳组装抑制活性。构效关系（SAR）研究表明，带有适当芳香侧链的化合物具有潜在的抗病毒活性。分子建模实验揭示了它们可以以与CAP-1相同的方式与CA结合并占据另外两个凹槽的分子机制。 (C) 2010 年，爱思唯尔有限公司出版。
We synthesized a series of acylhydrazone compounds bearing naturally occurring amino acids' side chains as HIV assembly inhibitors. Biological evaluation indicated that the compounds had anti-SIV and capsid assembly inhibitory activities. The structure-activity relationship (SAR) study showed that compounds bearing proper aromatic side chains had potential antiviral activities. The molecular modeling experiments revealed the molecular mechanism that they could bind to CA in the same manner as CAP-1 and occupy two more grooves. (C) 2010 Published by Elsevier Ltd.