Prevalence of major depression one year after predictive testing for Huntington's disease.
Prevalence of major depression one year after predictive testing for Huntington's disease.
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亨廷顿病预测测试一年后重度抑郁症的患病率。
DOI：
10.1089/gte.2004.8.114
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Brandt,Jason
中科院分区：
文献类型：
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作者：
Codori,Ann-Marie;Slavney,PhillipR;Rosenblatt,Adam;Brandt,Jason
在进行亨廷顿病（HD）预测性检测后，精神病住院、自杀未遂和自杀未遂是罕见的。案例研究表明，重度抑郁症可能是测试的结果，尽管没有研究表明这种情况有多普遍。本研究评估了抑郁症的患病率在第一年后披露。我们对153人（50人检测阳性，103人检测阴性）进行了回顾性数据和图表审查，每3个月进行一次抑郁症评估。测试前患有重度抑郁症的“阳性”和“阴性”患者的百分比在基线上没有显着差异（分别为14%和12%）。一位资深精神病学家回顾了情感障碍和精神分裂症量表-变化版、贝克抑郁量表和每次随访联系的临床记录中的数据。阳性患者中重度抑郁症的1年患病率为6.0%，而阴性患者中重度抑郁症的1年患病率为3.0%（p = 0.30），估计人口患病率为3%。无论是否被诊断为重度抑郁症，一年内有临床意义的抑郁症状的患病率在阳性组为20.0%，在阴性组为12.6%（p = 0.17）。虽然没有统计学意义，但抑郁症状和重性抑郁症在检测呈阳性的人中发生得更频繁。尽管有一些相反的证据，包括我们自己的研究，HD的阳性预测测试在心理上并不是良性的。临床测试项目应在测试后评估患者的抑郁症状，有临床显著主诉的患者应转诊给心理健康专业人员。
Psychiatric hospitalizations, completed suicides, and suicide attempts are rare after predictive testing for Huntington's disease (HD). Case studies have shown that major depression can be a consequence of being tested, although no studies have shown how common this is. The present study evaluated the prevalence of major depression during the first year after disclosure. We conducted retrospective data and chart reviews of 153 persons (50 testing positive, 103 testing negative) evaluated every 3 months for depression. There was no significant baseline difference in the percentage of “positives” and “negatives” who had pre-testing major depressive episodes (14% vs. 12%, respectively). A senior psychiatrist reviewed data from the Schedule for Affective Disorders and Schizophrenia–Change Version, from the Beck Depression Inventory, and from clinical notes for every follow-up contact completed. The 1-year prevalence of major depression among positives was 6.0%, compared to 3.0% among negatives (p = 0.30), and an estimated 3% population prevalence. One-year prevalence of clinically significant depressive symptoms, whether or not major depression was diagnosed, was 20.0% in positives and 12.6% in negatives (p = 0.17). Although not statistically significant, depressive symptoms and major depression occurred more frequently among those who tested positive. Despite some evidence to the contrary, including our own studies, a positive predictive test for HD is not psychologically benign. Clinical testing programs should assess patients for depressive symptoms after testing, and patients with clinically significant complaints should be referred to a mental health professional.