DIFFERENCES IN THE COLLATERALIZATION OF NEURONAL PROJECTIONS FROM THE DORSAL COLUMN NUCLEI AND LATERAL CERVICAL NUCLEUS TO THE THALAMUS AND TECTUM IN THE CAT - AN ANATOMICAL STUDY USING 2 DIFFERENT DOUBLE-LABELING TECHNIQUES
DIFFERENCES IN THE COLLATERALIZATION OF NEURONAL PROJECTIONS FROM THE DORSAL COLUMN NUCLEI AND LATERAL CERVICAL NUCLEUS TO THE THALAMUS AND TECTUM IN THE CAT - AN ANATOMICAL STUDY USING 2 DIFFERENT DOUBLE-LABELING TECHNIQUES
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DOI：
10.1016/0006-8993(80)90141-9
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发表时间：
1980-01-01
期刊：
影响因子：
2.9
通讯作者：
FLINK, R
中科院分区：
文献类型：
--
作者：
BERKLEY, KJ;BLOMQVIST, A;FLINK, R
背柱核（DCN）和颈外侧核（LCN）投射至间脑和顶盖。为了确定哪些神经元投射到这些靶点以及是否有任何神经元具有侧支投射，使用了Hayes和Rustioni以及Kuypers等人开发的双逆行标记技术。在DCN内，投射到间脑的神经元位于不同的位置，并具有不同的形态比投射到顶盖。优先位于DCN复合体中间部分内的间脑投射神经元主要是大的（直径> 15 μ m）和圆形的。顶盖投射神经元通常位于薄束核和楔束核的边缘沿着或它们之间，最常出现在DCN复合体的中间部分之外（即，主要是吻侧，经常是尾侧）。这些投射到顶盖的神经元大小不等，通常呈椭圆形或梭形。LCN中投射到顶盖或间脑的神经元在形态上没有差异，并且两组中的神经元具有不同的大小和形状。它们是混杂的，主要分布在核的外侧2/3内。另一类神经元，有时占标记群体的40%以上，具有对两个终末靶点的侧支投射。这些双标记的神经元与其他标记的神经元混杂在一起。DCN和LCN神经元的分歧模式的差异是显而易见的。解剖学和电生理学表明，不同投射的DCN神经元可能具有不同的功能特性。LCN神经元在功能上并不明显。
The dorsal column nuclei (DCN) and the lateral cervical nucleus (LCN) project to the diencephalon and tectum. To determine which neurons project to these targets and whether any have collateral projections, the double-retrograde labeling techniques developed by Hayes and Rustioni, and Kuypers et al were used. Within the DCN, neurons projecting to the diencephalon were located differently and had a different morphology than those projecting to the tectum. The diencephalic-projecting neurons, which were preferentially located within the middle part of the DCN complex, were mainly large (> 15 .mu.m diameter) and round. The tectal-projecting neurons, often located along the edges of the gracile and cuneate nuclei or between them, were most often found outside of the middle parts of the DCN complex (i.e., predominantly rostrally and frequently caudally). These tectal-projecting neurons varied in size and were usually oval or fusiform in shape. Neurons in the LCN which projected to the tectum or diencephalon did not differ morphologically and in both groups were of various sizes and shapes. They were intermixed haphazardly, predominantly within the lateral 2/3 of the nucleus. Another class of neurons, sometimes constituting > 40% of the labeled population, had collateral projections to both terminal targets. These double-labeled neurons were haphazardly mixed with other labled neurons. Differences in the divergence patterns of DCN and LCN neurons are evident. The anatomy and electrophysiology suggest DCN neurons with different projections may have different functional properties. LCN neurons do not appear functionally distinct.