Hormone exposure and its suppressive effect on risk of high-grade gliomas among patients with breast cancer.
Hormone exposure and its suppressive effect on risk of high-grade gliomas among patients with breast cancer.
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DOI：
10.1016/j.jocn.2021.10.029
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发表时间：
2021-12
影响因子：
2
通讯作者：
Esquenazi, Yoshua
中科院分区：
文献类型：
--
作者：
Lopez-Garcia, Carlos A.;Lopez-Rivera, Victor;Dono, Antonio;Salazar-Marioni, Sergio;Novo, Jorge E.;Sheth, Sunil A.;Ballester, Leomar Y.;Esquenazi, Yoshua
先前的报告表明，高级别神经胶质瘤 (HGG) 中存在雌激素和孕激素受体的表达，但乳腺癌 (BC) 患者中激素受体阳性疾病与 HHG 风险之间的关系仍不清楚。使用 SEER 18 登记库（2000-2017 年），我们检查了 HGG 和 BC 发病率的时间趋势。计算标准化发病率以评估 BC 患者随后发生 HGG 的风险。在研究期间，男性和女性的 BC 和 HGG 发病率保持相当。在 976,134 名 BC 患者中，我们发现女性 HGG 的发生率有所下降，但男性则没有。患有激素受体阳性疾病的女性 BC 患者患胶质母细胞瘤和间变性星形细胞瘤的风险较低。我们的研究结果暗示了激素暴露在 HGG 发育中的保护作用，这可能会导致针对激素途径的疗法的开发。
Prior reports demonstrate the expression of estrogen and progesterone receptors in high-grade gliomas (HGGs), but the relationship between hormone receptor-positive disease and risk of HHGs in patients with breast cancer (BC) remains uncharacterized. Using the SEER 18 registries (2000–2017), we examined the temporal trend of the incidence of HGGs and BC. The standardized incidence ratio was calculated to assess the risk of subsequent HGG in BC patients. During the study period, the incidence of BC and HGGs remained comparable for men and women. Among 976,134 patients with BC, we found a decreased incidence of HGGs in females, but not in males. Female BC patients with hormone receptor-positive disease were at a lower risk of developing glioblastoma and anaplastic astrocytoma. Our study findings allude to the protective role of hormone exposure in the development of HGGs, which may lead to the development of therapies targeting hormonal pathways.
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