The neurobiology of benzodiazepine receptors in panic disorder and post-traumatic stress disorder
The neurobiology of benzodiazepine receptors in panic disorder and post-traumatic stress disorder
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DOI：
10.1002/smi.1165
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发表时间：
2008-02-01
影响因子：
4.1
通讯作者：
Burrows, Graham D.
中科院分区：
文献类型：
--
作者：
Ellen, Steven;Olver, James;Burrows, Graham D.
γ-氨基丁酸（GABA）是中枢神经系统中最重要的抑制性神经递质，苯二氮卓类（BZ）通过GABA受体复合物上的结合位点起作用。GABA-BZ受体复合物的神经生物学正越来越多地被理解为间接和直接研究受体复合物的成像和药理学技术的改进。本文概述了BZ受体异常的证据在惊恐障碍和创伤后应激障碍。版权所有（C）2008约翰威利父子有限公司
Gamma-aminobutyric acid (GABA) is quantitatively the most important inhibitory neurotransmitter in the central nervous system, and benzodiazepines (BZs) act via a binding site on the GABA receptor complex. The neurobiology of the GABA-BZ receptor complex is being increasingly understood as imaging and pharmacological techniques to study the receptor complex both indirectly and directly improve. This paper outlines the evidence for BZ receptor abnormalities in panic disorder and post-traumatic stress disorder. Copyright (C) 2008 John Wiley & Sons, Ltd.