Reduced communication between frontal and temporal lobes during talking in schizophrenia
Reduced communication between frontal and temporal lobes during talking in schizophrenia
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DOI：
10.1016/s0006-3223(01)01335-x
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发表时间：
2002-03-15
影响因子：
10.6
通讯作者：
Roth, WT
中科院分区：
文献类型：
--
作者：
Ford, JM;Mathalon, DH;Roth, WT
背景：产生言语和口头思维的额叶和感知它们的颞叶之间的交流可能是通过必然的放电发生的。它的功能障碍可能是无法识别内部语言是自我产生的，并解释了精神分裂症患者的幻听。方法：记录10名健康成人和12名精神分裂症患者(DSM-IV)在两种情况下的脑电：大声说话和听自己的回放语音。在两种情况下，事件相关脑电对声刺激的一致性被计算在额叶和时间对之间，在Delta、theta、α、beta和Gamma频段。结果：在额颞区之间，交谈产生了比倾听更大的一致性。所有频段；然而，在较低的频率(德尔塔和西塔)，存在显著的群体和条件的交互作用。这一发现表明，患者在交谈过程中没有表现出连贯的增加，特别是在左侧大脑半球的言语产生和言语接收区，特别是在容易产生幻觉的患者。结论：额颞部功能连接的减少可能是精神分裂症患者将内部想法错误归因于外部声音的原因之一。(C)2002年生物精神病学学会。
Background: Communication between the frontal lobes, where speech and verbal thoughts are generated, and the temporal lobes, where they are perceived, may occur through the action of a corollary discharge. Its dysfunction may underlie failure to recognize inner speech as self-generated and account for auditory hallucinations in schizophrenia.Methods: Electroencephalogram was recorded from 10 healthy adults and 12 patients with schizophrenia (DSM-IV) in two conditions: talking aloud and listening to their own played-back speech. Event-related electroencephalogram coherence to acoustic stimuli presented during both conditions was calculated between frontal and temporal pairs, for delta, theta, alpha, beta, and gamma frequency bands.Results: Talking produced greater coherence than listening between frontal-temporal regions in. all frequency bands; however, in the lower frequencies (delta and theta), there were significant interactions of group and condition. This finding revealed that patients failed to show an increase in coherence during talking, especially over the speech production and speech reception areas of the left hemisphere, and especially in patients prone to hallucinate.Conclusions: Reduced fronto-temporal functional connectivity may contribute to the misattribution of inner thoughts to external voices in schizophrenia. (C) 2002 Society of Biological Psychiatry.