Cancer stem cells converted from pluripotent stem cells and the cancerous niche.
Cancer stem cells converted from pluripotent stem cells and the cancerous niche.
复制标题
DOI：
10.46582/jsrm.1001002
复制
发表时间：
2014
影响因子：
2.7
通讯作者：
Seno M
中科院分区：
文献类型：
--
作者：
Kasai T;Chen L;Mizutani A;Kudoh T;Murakami H;Fu L;Seno M
目前，肿瘤干细胞被认为是所有癌症生长、转移、侵袭和复发的重要调控因子。肿瘤干细胞具有持续增殖和自我更新的特点，并具有分化潜能，而干细胞被认为在微环境的影响下向成熟细胞的组织特异性表型分化。癌症干细胞应追溯到在微环境影响下诱发恶性肿瘤的干细胞。在这篇综述中，我们提出了这个微环境作为一个“癌症生态位”，并讨论了其在癌症干细胞形成和维持中的重要性，以及最近的实验结果，以诱导多能干细胞建立癌症干细胞模型。这些癌症干细胞模型将在未来的癌症研究和治疗应用中提供巨大的优势。
Nowadays, the cancer stem cells are considered to be significantly responsible for growth, metastasis, invasion and recurrence of all cancer. Cancer stem cells are typically characterized by continuous proliferation and self-renewal as well as by differentiation potential, while stem cells are considered to differentiate into tissue- specific phenotype of mature cells under the influence of micro-environment. Cancer stem cells should be traced to the stem cells under the influence of a micro-environment, which induces malignant tumors. In this review, we propose this micro-environment as a ‘cancerous niche’ and discuss its importance on the formation and maintenance of cancer stem cells with the recent experimental results to establish cancer stem cell models from induced pluripotent stem cells. These models of cancer stem cell will provide the great advantages in cancer research and its therapeutic applications in the future.