Why different rules are required for polygenic inheritance:: Lessons from studies of the DRD2 gene
Why different rules are required for polygenic inheritance:: Lessons from studies of the DRD2 gene
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DOI：
10.1016/s0741-8329(97)00178-x
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发表时间：
1998-07-01
期刊：
影响因子：
2.3
通讯作者：
Comings, DE
中科院分区：
文献类型：
--
作者：
Comings, DE
1990年，Blum、Noble和同事报告了D-2多巴胺受体基因（DRD2） Taq1A多态性的1个等位基因与严重酒精中毒之间的显著关联。随后，一些同时使用联系和关联技术的报告支持这一发现，而其他报告要么不支持，要么似乎不支持这种关联。尽管一些争议是由于D(2)A1等位基因在不同酗酒者和对照组中的频率存在真正的差异，但也有一些争议是由于经常试图将单基因疾病的规则应用于很可能是多因素、多基因疾病的疾病。当使用适合多基因遗传的规则时，争议的很大一部分得到了解决。这些规则，以及它们在DRD2基因在上瘾、冲动行为中的作用的应用，将被回顾。(C) 1998爱思唯尔科学有限公司
In 1990 Blum, Noble and coworkers reported a significant association between the 1 allele of the Taq1A polymorphism of the D-2 dopamine receptor gene (DRD2) and severe alcoholism. Subsequently, some reports using both linkage and association techniques supported this finding whereas others either did not, or seemed not to support this association. Although some of the controversy is due to true variability in the frequency of the D(2)A1 allele in different groups of alcoholics and controls, some is also due to the frequent attempt to apply the rules of single-gene disorders to what is in all likelihood a multifactorial, polygenic disorder. When the rules that are appropriate to polygenic inheritance are used a significant portion of the controversy is resolved. Those rules, and their application to the role of the DRD2 gene in addictive, impulsive behaviors, are reviewed. (C) 1998 Elsevier Science Inc.