Quantitative MR imaging evaluation of the cartilage thickness and subchondral bone area in patients with ACL-reconstructions 7 years after surgery
Quantitative MR imaging evaluation of the cartilage thickness and subchondral bone area in patients with ACL-reconstructions 7 years after surgery
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DOI：
10.1016/j.joca.2008.05.024
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发表时间：
2009-07-01
影响因子：
7
通讯作者：
Eckstein, F.
中科院分区：
文献类型：
--
作者：
Andreisek, G.;White, L. M.;Eckstein, F.
目的：应用定量和区域软骨磁共振成像（qMRI）技术评价前交叉韧带（ACL）重建术后7年行手术和对侧未行手术（健康）膝关节软骨厚度（ThC）和软骨下骨面积（tAB）。方法：对410例acl重建患者的病历进行回顾性分析。纳入52例患者（男/女，28/24，平均年龄33.3岁）。患者在1.5 t时使用冠状脂肪饱和3D破坏梯度回忆回声（SPGR）序列（TR/TE, 44/4 ms）进行KT-1000检测和双膝qMRI。采用分区域方法定量分析股胫软骨板中的ThC和tAB。此外，对股骨髁形状进行定性和定量评估。采用Bonferroni校正t检验统计分析手术与未手术膝关节的侧对侧差异。结果：3/52例（6%）患者KT-1000检测异常。手术组与未手术组相比，股骨外侧tAB明显降低（-9.2%），胫骨内侧tAB明显增大（+2%）（P < 0.001）。区域和分区域ThC侧对侧差异均小于0.1 mm，除股骨外外侧亚区外，其他差异均无统计学意义。手术膝关节股骨内侧髁扁平、宽（P < 0.001）。手术时软骨或半月板病变与术后7年ThC无显著相关性（P = 0.06-0.98）。结论：acl重建后7年，关节瓣和股骨形状发生变化，但手术和对侧未手术膝关节的分区域ThC无侧侧差异。(C) 2009国际骨关节炎研究学会。Elsevier Ltd.出版。版权所有。
Objective: To evaluate the cartilage thickness (ThC) and subchondral bone area (tAB) of the operated and contra-lateral non-operated (healthy) knees in patients with anterior cruciate ligament (ACL)-reconstruction 7 years after surgery using a quantitative and regional cartilage MR imaging (qMRI) technique.Methods: Charts of 410 patients with ACL-reconstructions were retrospectively reviewed. Fifty-two patients (male/female, 28/24; mean age, 33.3 years) were included. Patients underwent KT-1000 testing and qMRI of both knees using coronal fat-saturated 3D spoiled gradient-recalled echo (SPGR) sequences (TR/TE, 44/4 ms) at 1.5 T. Quantitative analyses of ThC and tAB in the femoro-tibial cartilage plates were performed using a subregional approach. In addition, qualitative and quantitative assessment of femoral condyle shapes was performed. t tests with Bonferroni corrections were used for statistical analysis of side-to-side differences between the operated and non-operated knees.Results: KT-1000 testing was abnormal in 3/52 patients (6%). Lateral femoral tAB was significantly lower (-9.2%), and medial tibial tAB was significantly larger (+2%) in the operated vs non-operated knee (P < 0.001). Regional and subregional ThC side-to-side differences were less than 0.1 mm and, except for the external lateral femoral subregion, they were not statistically significant. Flattened and broader shapes of medial femoral condyles (P < 0.001) were found in operated knees. No significant association of presence of cartilage or meniscus lesions at surgery with ThC 7 years post-operatively was found (P = 0.06-0.98).Conclusion: There is evidence for changes in the tAB and femoral shape 7 years post-ACL-reconstruction, but no side-to-side differences in subregional ThC were found between the operated and contra-lateral non-operated knees. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.