Avian influenza A (H5N1) infection in a patient in China, 2006.
Avian influenza A (H5N1) infection in a patient in China, 2006.
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2006 年中国一名患者感染甲型禽流感 (H5N1)
DOI：
10.1111/j.1750-2659.2007.00032.x
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发表时间：
2007-09
影响因子：
4.4
通讯作者：
Guan Y
中科院分区：
文献类型：
--
作者：
Chen X;Smith GJ;Zhou B;Qiu C;Wu WL;Li Y;Lu P;Duan L;Liu S;Yuan J;Yang G;Wang H;Cheng J;Jiang H;Peiris JS;Chen H;Yuen KY;Zhong N;Guan Y
背景自2004年以来，高致病性H5 N1禽流感病毒在欧亚大陆引起了越来越多的人感染。 到目前为止，人类感染H5 N1的死亡率已超过50%，部分原因是诊断和治疗的延误。 目的与方法2006年6月，我们报告了一名31岁的深圳患者感染H5 N1流感病毒。 为了确定可能的感染源，对同一时期从中国南方家禽和野鸟中获得的人分离株和其他H5 N1流感病毒进行了鉴定。 结果基因和抗原分析显示，人类H5 N1流感病毒（Shenzhen/406 H/06）纯粹源自禽类，与2006年初在香港家禽和野鸟身上发现的病毒关系最密切。 结论H5 N1流感病毒在华南地区禽类中的持续流行增加了该病毒向人类传播的机会。 这突显了继续监测家禽和野鸟以确定人类H5 N1感染来源的重要性。
Background Highly pathogenic avian influenza H5N1 virus has caused increasing human infection in Eurasia since 2004. So far, H5N1 human infection has been associated with over 50% mortality that is partly because of delay of diagnosis and treatment. Objectives and methods Here, we report that an H5N1 influenza virus infected a 31‐year‐old patient in Shenzhen in June 2006. To identify the possible source of the infection, the human isolate and other H5N1 influenza viruses obtained from poultry and wild birds in southern China during the same period of time were characterized. Results Genetic and antigenic analyses revealed that the human H5N1 influenza virus, Shenzhen/406H/06, is of purely avian origin and is most closely related to viruses detected in poultry and wild birds in Hong Kong in early 2006. Conclusions The findings of the present study suggest that the continued endemicity of H5N1 influenza virus in the poultry in southern China increases the chance for introduction of the virus to humans. This highlights the importance of continued surveillance of poultry and wild birds for determining the source for human H5N1 infection.