Diagnosis of sleep-related breathing disorders by visual analysis of transthoracic impedance signals in pacemakers
Diagnosis of sleep-related breathing disorders by visual analysis of transthoracic impedance signals in pacemakers
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DOI：
10.1161/01.cir.0000145540.36097.eb
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发表时间：
2004-10-26
期刊：
影响因子：
37.8
通讯作者：
Wilkoff, BL
中科院分区：
文献类型：
--
作者：
Scharf, C;Cho, YK;Wilkoff, BL
背景 心脏起搏器的每分钟通气量传感器通过起搏器外壳和电极尖端之间的经胸廓阻抗变化来测量通气量。我们研究了这种技术是否可以检测与睡眠相关的呼吸障碍。方法和结果 - 在 22 名患者中，起搏器每分通气量传感器在夜间测量的经胸阻抗信号的模拟波形被可视化，对呼吸暂停/呼吸不足事件进行评分，并与同步多导睡眠图进行比较。经胸阻抗信号分析正确识别了所有患者是否存在中度至重度睡眠呼吸暂停（呼吸暂停/呼吸不足指数，AHI >20 h(-1)）（接收器操作特征，ROC = 1.0）。 AHI 评分大于或等于 5 h(-1) 和大于或等于 10 h(-1) 的 ROC 显示曲线下面积为 0.95，P
Background-Minute ventilation sensors of cardiac pacemakers measure ventilation by means of transthoracic impedance changes between the pacemaker case and the electrode tip. We investigated whether this technique might detect sleep-related breathing disorders.Methods and Results-In 22 patients, analog waveforms of the transthoracic impedance signal measured by the pacemaker minute ventilation sensor over the course of a night were visualized, scored for apnea/hypopnea events, and compared with simultaneous polysomnography. Analysis of transthoracic impedance signals correctly identified the presence or absence of moderate to severe sleep apnea (apnea/hypopnea index, AHI >20 h(-1)) in all patients (receiver operating characteristics, ROC = 1.0). The ROC for AHI scores of greater than or equal to5 h(-1) and greater than or equal to10 h(-1) showed an area under the curve of 0.95, P