Periodic exposure to a brief light signal stimulates neuroendocrine-gonadal activity in golden hamsters.
Periodic exposure to a brief light signal stimulates neuroendocrine-gonadal activity in golden hamsters.
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定期暴露于短暂的光信号会刺激金仓鼠的神经内分泌性腺活动。
DOI：
10.1002/j.1939-4640.1984.tb00777.x
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发表时间：
1984
影响因子：
--
通讯作者：
Turek,FW
中科院分区：
文献类型：
--
作者：
Earnest,DJ;Turek,FW
使用夜间中断范例检查了周期性光脉冲对雄性金黄仓鼠神经内分泌-性腺活动的光周期效应。将LD 14：10每笼饲养3 - 5只成年雄性仓鼠置于单独的笼中，每个笼配备一个转轮，或在公共饲养条件下饲养，不使用转轮。然后将动物转移至LD 6：18或LD 6：18光照周期，每2、4或7天进行一次周期性10秒夜间中断（关灯后8小时）。正如预期，暴露于LD 6：18 11周诱导单独和共同饲养动物的睾丸和精囊完全消退，伴有低血清LH和FSH水平。然而，在LD 6：18每隔一天接受10秒夜间中断的单独圈养动物中，配对睾丸和精囊重量以及血清促性腺激素水平维持在与暴露于光刺激长日照的仓鼠中正常观察到的值相当的值。此外，每4天或7天对单独饲养的动物进行一次周期性10秒的夜间中断，并使用转轮，足以部分或完全阻断短日照对神经内分泌-性腺活动的抑制作用。每2天、4天或7天接受一次10秒光脉冲的社区饲养仓鼠也表现出配对睾丸和精囊重量以及血清促性腺激素水平，其始终高于仅暴露于LD 6：18的动物获得的值。然而，在公共饲养的动物中，每次夜间中断范例在维持睾丸和精囊重量方面的功效显著低于在使用转轮的动物中观察到的功效。这些结果表明，每两次、四次、或者在抑制性光周期的暗期期间的7天可以影响作为性腺功能的光周期调节的基础的神经内分泌事件。这种实验方法，即在特定的田园时间周期性地给予离散刺激以诱导光周期反应，应该为研究光调节哺乳动物神经内分泌-性腺轴的生理机制提供有价值的模型。
The photoperiodic effects of a periodic light pulse on neuroendocrine‐gonadal activity in the male golden hamster was examined using a night interruption paradigm. Adult male hamsters that had been housed 3 to 5 per cage on LD 14:10 were placed either in individual cages, each equipped with a running wheel, or maintained in communal housing conditions, without access to a running wheel. Animals were then transferred to either LD 6:18 or to a LD 6:18 light cycle with a periodic 10‐second night interruption (8 hours after lights off) occurring once every two, four, or seven days. As expected, exposure to LD 6:18 for 11 weeks induced complete regression of the testes and seminal vesicles, accompanied by low serum levels of LH and FSH, in both individually and communally‐housed animals. However, in individually‐housed animals receiving a 10‐second night interruption every other day on LD 6:18, paired testis and seminal vesicle weights, as well as serum gonadotropin levels, were maintained at values comparable to those normally observed in hamsters exposed to photostimulatory long days. Furthermore, the presentation of a periodic 10‐second night interruption once every four or seven days to individually‐housed animals with access to a running wheel was sufficient to partially or totally block the inhibitory effects of short days on neuroendocrine‐gonadal activity. Communally‐housed hamsters receiving a 10‐second light pulse once every two, four, or seven days also exhibited paired testis and seminal vesicle weights, as well as serum gonadotropin levels, that were consistently higher than the values obtained for animals exposed only to LD 6:18. However, the efficacy of each night interruption paradigm in maintaining testicular and seminal vesicle weight in communally‐housed animals was considerably less than that observed for animals with access to a running wheel.These results demonstrate that the periodic presentation of a brief photic stimulus once every two, four, or seven days during the dark phase of an inhibitory light cycle can influence the neuroendocrine events underlying the photoperiodic regulation of gonadal function. This experimental approach, whereby a discrete stimulus is periodically administered at a specific arcadian time to induce a photoperiodic response, should provide a valuable model for examining the physiologic mechanisms by which light regulates the neuroendocrine‐gonadal axis in mammals.