Highly stereoselective construction of novel dispirooxindole-imidazolidines via self-1,3-dipolar cyclization of ketimines
Highly stereoselective construction of novel dispirooxindole-imidazolidines via self-1,3-dipolar cyclization of ketimines
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DOI：
10.1039/c5ob00954e
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发表时间：
2015-01-01
影响因子：
3.2
通讯作者：
Yang, Hua
中科院分区：
文献类型：
--
作者：
Sun, Yan-Hua;Xiong, Yu;Yang, Hua
通过酸促进的酮亚胺与苯胺的自1，3-偶极环加成反应，成功地组装了双螺吲哚-咪唑烷环体系。通常，获得了优异的非对映选择性（仅形成单一立体异构体）和良好的产率（高达94%）。因此，这种自我-1，3-偶极环加成协议提供了一个新的dipiroheterocyclic骨架容易获得。
An acid-promoted self-1,3-dipolar cycloaddition of ketimines derived from isatins and benzylamines was successfully developed to assemble unprecedented dispirooxindole-imidazolidine ring systems. Generally, excellent diastereoselectivities (only a single stereoisomer formed) and good yields (up to 94%) were obtained. Consequently, this self-1,3-dipolar cycloaddition protocol offers facile access to a novel dispiroheterocyclic skeleton.