Central physiological correlates of ageing and presbycusis in mice.
Central physiological correlates of ageing and presbycusis in mice.
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DOI：
10.3109/00016489109127271
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
J. Willott
中科院分区：
文献类型：
--
作者：
J. Willott
衰老小鼠中枢听觉系统神经元的反应表明了与年龄相关的听力问题的几个来源。在老年性耳聋小鼠中，频率的中央表征（音调组织）被破坏，这意味着频率编码问题的原因。在只有轻微听力损失的老年小鼠中，正常反应的神经元与“迟钝”的神经元共存，这表明存在一个磨损过程，对某些神经元的影响比对其他神经元的影响更大。老年小鼠神经元的自发活动增加，这意味着生理信噪比降低。与年龄相关的听力损失的影响是更严重的腹侧耳蜗核比背侧耳蜗核，这表明各种功能电路可能或多或少容易受到老年性耳聋。
Responses of neurons in the central auditory system of ageing mice suggest several sources of age-related problems in hearing. The central representation of frequency (tonotopic organization) is disrupted in mice with presbycusis, implying a cause of problems with frequency coding. In very old mice with only minimal hearing loss, normal-responding neurons co-exist with "sluggish" neurons, which suggests there is a process of attrition that affects some neurons more than others. Spontaneous activity increases in neurons of older mice, implying a decrease in the physiological signal-to-noise ratio. The effects of age-related hearing loss are more severe in the ventral cochlear nucleus than in the dorsal cochlear nucleus, suggesting that various functional circuits may be more or less vulnerable to presbycusis.