TOXIC ACTION ON BACTERIA OF IRRADIATED SOLUTIONS OF COPPER COMPOUNDS
TOXIC ACTION ON BACTERIA OF IRRADIATED SOLUTIONS OF COPPER COMPOUNDS
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DOI：
10.2307/3572048
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发表时间：
1967-01-01
影响因子：
3.4
通讯作者：
CRAMP, WA
中科院分区：
文献类型：
--
作者：
CRAMP, WA
几种铜化合物的溶液在辐照时已被证明对细菌有毒。只有在严格缺氧条件下进行辐照和毒性测量时才能获得这种效果。得出的结论是，辐射将铜化合物转化为对细菌试验系统有毒的亚铜化合物。并不是所有经过辐射的铜化合物都是有毒的，这可能是因为某些化合物中的铜原子不能迁移到细菌细胞内的重要部位。预辐照的细菌被证明是不太敏感的铜化合物的辐照溶液的毒性作用，和照射的细菌在铜络合物的存在下，导致敏化的细菌照射。这种相互作用表明辐射和被辐射的铜配合物的致死作用可能发生在同一位点或通过相同的机制，并推导出辐射和细菌-铜配合物相互作用的可能顺序。
Solutions of several copper compounds when irradiated have been shown to be toxic to bacteria. The effect was obtained only when the irradiation and toxicity measurements were under conditions of rigorous anoxia. It was concluded that radiation converted cupric compounds to cuprous compounds toxic to the bacterial test system. Not all irradiated copper compounds were toxic, possibly because the copper atom in some compounds could not migrate to a vital site within the bacterial cell. Preirradiated bacteria were shown to be much less sensitive to the toxic action of irradiated solutions of copper compounds, and irradiation of bacteria in the presence of copper complexes led to sensitization of the bacteria to irradiation. This interaction indicated that the lethal action of both radiation and irradiated copper complexes could be at the same site or through the same mechanism, and a possible sequence of Irradiation and bacteria-copper complex interaction Was deduced.