Widespread Traces of Lytic Kaposi Sarcoma-Associated Herpesvirus in Primary Effusion Lymphoma at Single-Cell Resolution.

Widespread Traces of Lytic Kaposi Sarcoma-Associated Herpesvirus in Primary Effusion Lymphoma at Single-Cell Resolution.
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DOI:
10.1128/mra.00851-20
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发表时间:
2020-11-05
影响因子:
0.8
通讯作者:
Miranda JL
Miranda JL
中科院分区:
其他
文献类型:
--
作者:
Rondeau NC;Finlayson MO;Miranda JL

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原发性渗出性淋巴瘤 (PEL) 的癌细胞通常含有卡波西肉瘤相关疱疹病毒 (KSHV) 和 Epstein-Barr 病毒 (EBV)。我们使用单细胞 RNA 测序测量了 PEL 细胞培养模型中人类、KSHV 和 EBV 转录的相互作用。数据检测到裂解性 KSHV 基因的广泛微量表达。原发性渗出性淋巴瘤 (PEL) 的癌细胞通常含有卡波西肉瘤相关疱疹病毒 (KSHV) 和 Epstein-Barr 病毒 (EBV)。我们使用单细胞 RNA 测序测量了 PEL 细胞培养模型中人类、KSHV 和 EBV 转录的相互作用。数据检测到裂解性 KSHV 基因的广泛微量表达。
Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes. Cancer cells of primary effusion lymphoma (PEL) often contain both Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). We measured the interplay of human, KSHV, and EBV transcription in a cell culture model of PEL using single-cell RNA sequencing. The data detect widespread trace expression of lytic KSHV genes.