A New Strategy for the Synthesisof Himbacine
A New Strategy for the Synthesisof Himbacine
复制标题
合成辛巴辛的新策略
DOI：
10.1055/s-0030-1259918
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发表时间：
2011
期刊：
影响因子：
2
通讯作者：
R. McCarthy
中科院分区：
文献类型：
--
作者：
M. Casey;R. McCarthy
一种新的战略，为大会的himbacine和类似物，显示出强大的生物活性，描述。发展了一条四步合成关键中间体的路线，其中关键步骤是高度非对映选择性的Michael―Dieckmann多米诺反应。使用的对映体富集的迈克尔受体，很容易获得的不对称二羟基化反应，允许动力学解析的迈克尔供体，这是本身制备的多米诺反应。
A new strategy for the assembly of himbacine and analogues, which display potent biological activity, is described. A four-step route to a key intermediate has been developed, in which the key step is a highly diastereoselective Michael―Dieckmann domino reaction. Use of an enantioenriched Michael acceptor, readily obtained by an asymmetric dihydroxylation reaction, allowed kinetic resolution of the Michael donor, which was itself prepared by a domino reaction.