Activation of complement by renal tissues from patients with IgA nephropathy.
Activation of complement by renal tissues from patients with IgA nephropathy.
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IgA 肾病患者肾组织对补体的激活。
DOI：
10.1136/jcp.34.1.35
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发表时间：
1981
影响因子：
3.4
通讯作者：
H. Sakai
中科院分区：
文献类型：
--
作者：
Y. Tomino;M. Endoh;Y. Nomoto;H. Sakai
在一项肾脏组织补体活化的研究中，我们从IgA肾病和其他肾小球疾病患者身上获得肾活检标本。将这些标本与新鲜冷冻的豚鼠血清孵育，用fitc偶联抗豚鼠补体抗血清免疫荧光染色评价其对豚鼠补体系统的激活作用。结果表明，补体的替代途径在IgA肾病患者的肾组织中被原位激活。因此，分析这些患者体内补体的原位活化有助于阐明各种肾小球疾病中补体活化的机制。
In a study of complement activation by renal tissues, renal biopsy specimens were obtained from patients with IgA nephropathy and other glomerular diseases. These specimens were incubated with freshly frozen guinea-pig serum, and the activation of guinea-pig complement systems was evaluated by immunofluorescent staining with FITC-conjugated anti-guinea-pig complement antisera. It was shown that the alternative pathway of the complement was activated in situ in renal tissues from patients with IgA nephropathy. it is suggested that analysis of in situ activation of complement in such patients is useful for elucidating the mechanism of complement activation in various glomerular diseases.