Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.
Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.
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DOI：
10.1002/eji.201141876
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发表时间：
2011-12
影响因子：
5.4
通讯作者：
Kobayashi, Koichi S.
中科院分区：
文献类型：
--
作者：
Caetano, Braulia C.;Biswas, Amlan;Lima-Junior, Djalma S.;Benevides, Luciana;Mineo, Tiago W. P.;Horta, Catarina V.;Lee, Kyoung-Hee;Silva, Joao S.;Gazzinelli, Ricardo T.;Zamboni, Dario S.;Kobayashi, Koichi S.
Nod2 belongs to the NLR family of proteins and senses bacterial cell wall components to initiate innate immune responses against various pathogens. Recently it has been reported that T cell-intrinsic expression of Nod2 promotes host defense against Toxoplasma gondii infection by inducing type 1 immunity. Here we present results that demonstrate that Nod2 does not play a role in the defense against T. gondii infection. Nod2-deficient mice were fully capable of inducing Th1 immune responses and did not show enhanced susceptibility to infection. Upon T cell receptor stimulation in vitro, Nod2-deficient CD4+ T cells showed normal activation, IL-2 production, proliferation and Th1/2 differentiation. Nod2 mRNA and protein are expressed in CD4+ T and CD8+ T cells at substantial levels. Therefore Nod2, although expressed in CD4+ T cells, does not have an intrinsic function in T cell activation and differentiation.
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DOI：
10.1038/nri2335
发表时间：
2008-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1073/pnas.0907722106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Petnicki-Ocwieja, Tanja;Hrncir, Tomas;Kobayashi, Koichi S.
通讯作者：
Kobayashi, Koichi S.
影响因子：
4.8
作者：
Girardin, SE;Travassos, LH;Mengin-Lecreulx, D
通讯作者：
Mengin-Lecreulx, D
影响因子：
32.4
作者：
Shaw PJ;Barr MJ;Lukens JR;McGargill MA;Chi H;Mak TW;Kanneganti TD
通讯作者：
Kanneganti TD
影响因子：
4.8
作者：
Hasegawa, Mizuho;Yang, Kangkang;Inohara, Naohiro
通讯作者：
Inohara, Naohiro