Measurement and meaning of apolipoprotein AI and apolipoprotein B plasma levels
Measurement and meaning of apolipoprotein AI and apolipoprotein B plasma levels
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DOI：
10.1111/j.1365-2796.2006.01648.x
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发表时间：
2006-05-01
影响因子：
11.1
通讯作者：
Packard, CJ
中科院分区：
文献类型：
--
作者：
Marcovina, S;Packard, CJ
载脂蛋白AI和B是脂蛋白颗粒的结构组分，也是包封的脂质、胆固醇和甘油三酯的代谢命运的决定因素。这些载脂蛋白的精确测定的发展为它们作为冠心病风险的预测因子开辟了道路。AI和载脂蛋白B水平的解释最好是在个体代谢状态的背景知识下进行的，特别是甘油三酯浓度所反映的脂解能力。一般来说，甘油三酯升高的患者不仅apo B/apo AI比值升高，而且含apo B的脂蛋白停留时间延长，因此有充分的机会发生修饰和损伤。评估载脂蛋白水平有助于风险预测，并可用于定制治疗。
Apolipoproteins AI and B are structural components of lipoprotein particles, and also determinants of the metabolic fate of the encapsulated lipid, cholesterol and triglyceride. Development of accurate assays for these apolipoproteins has opened the way for their use as predictors of coronary heart disease risk. Interpretation of AI and apo B levels is best undertaken with background knowledge of the metabolic status of an individual, especially the lipolytic capacity as reflected in the triglyceride concentration. Those with raised triglyceride, in general, not only have an elevated apo B/apo AI ratio, but also apo B-containing lipoproteins with a prolonged residence time and hence ample opportunity for modification and damage. Assessment of apolipoprotein levels is an aid to risk prediction and can be useful in tailoring treatment.