Transglutaminases and their regulation: implications for polyamine metabolism.
Transglutaminases and their regulation: implications for polyamine metabolism.
复制标题
转谷氨酰胺酶及其调节：对多胺代谢的影响。
DOI：
10.1007/978-1-4684-5637-0_34
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发表时间：
1988
影响因子：
--
通讯作者：
Stein,JP
中科院分区：
文献类型：
--
作者：
Davies,PJ;Chiocca,EA;Basilion,JP;Poddar,S;Stein,JP
谷氨酰胺转胺酶是一组催化蛋白质结合谷氨酰胺残基翻译后修饰的酶。这些酶的主要生理作用似乎是通过促进蛋白质结合的谷氨酰胺和赖氨酸残基之间形成异肽键来交联蛋白质。这些酶还催化多胺与蛋白质的共价结合，后者的活性导致了它们参与多胺作用生物学的猜测。在本报告中，我们将简要回顾考虑谷氨酰胺转胺酶作为多胺代谢成分的理论和实验证据。
Transglutaminases are a group of enzymes that catalyze the posttranslational modification of protein-bound glutamine residues. It appears that the major physiological role of these enzymes is to crosslink proteins by promoting the formation of isopeptide bonds between protein-bound glutamine and lysine residues. These enzymes also catalyze the covalent conjugation of polyamines to proteins and this latter activity has led to speculation about their involvement in the biology of polyamine action. In this report we would like to present a brief review of the theoretical and experimental evidence for considering transglutaminases as components in polyamine metabolism.