IMPACT OF AGE ON THE CARDIOVASCULAR-RESPONSE TO DYNAMIC UPRIGHT EXERCISE IN HEALTHY-MEN AND WOMEN
IMPACT OF AGE ON THE CARDIOVASCULAR-RESPONSE TO DYNAMIC UPRIGHT EXERCISE IN HEALTHY-MEN AND WOMEN
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DOI：
10.1152/jappl.1995.78.3.890
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发表时间：
1995-03-01
影响因子：
3.3
通讯作者：
LAKATTA, EG
中科院分区：
文献类型：
--
作者：
FLEG, JL;OCONNOR, F;LAKATTA, EG
为了研究年龄是否不同地改变了男性和女性对运动的生理反应，我们对来自巴尔的摩老龄化纵向研究的200名年龄在22-86岁之间的健康久坐志愿者（121名男性和79名女性）进行了门控放射性核素心室造影，测量了静息和峰值直立周期运动时的左心室容积。在坐位休息时，两种性别的受试者都出现了与年龄相关的心率（HR）下降和收缩压升高。男性的静息心脏指数（CI）和全身血管阻力（TSVR）不随年龄变化，而女性的静息CI下降16%，TSVR增加46%。男性，而不是女性，表现出与年龄相关的增加类似于20%的坐位舒张末期容积指数（EDVI），收缩末期容积指数（ESVI），每搏输出量指数在这个年龄跨度。峰值周期工作率随年龄下降，男女均为40%，但在任何年龄，即使在体重正常化后，男性的峰值周期工作率也高于女性。在最大努力时，射血分数（EF）、HR和CI随年龄的增加而降低，而ESVI和TSVR在两种性别中均增加; EDVI随年龄增加35%，男性每搏作功指数（SWI）增加19%，但两者均与女性年龄无关;每搏量指数在两种性别中均不随年龄变化。当血流动力学被表示为从休息到峰值努力的变化作为心血管储备功能的指数时，两种性别都表现出与年龄相关的EDVI和ESVI增加以及EF、HR和CI降低。然而，运动引起的ESVI降低和EF，CI和SWI从休息时的增加在男性中比女性更大。因此，年龄和性别对力竭性直立自行车运动的心脏反应均有显著影响。
To examine whether age differentially modifies the physiological response to exercise in men and women, we performed gated radionuclide ventriculography with measurement of left ventricular volumes at rest and during peak upright cycle exercise in 200 rigorously screened healthy sedentary volunteers (121 men and 79 women) aged 22-86 yr from the Baltimore Longitudinal Study of Aging. At rest in the sitting position, age-associated declines in heart rate (HR) and increases in systolic blood pressure occurred in both sexes. Whereas resting cardiac index (CI) and total systemic vascular resistance (TSVR) in men did not vary with age, in women resting CI decreased 16% and TSVR increased 46% over the six-decade age span. Men, but not women, demonstrated an age-associated increase of similar to 20% in sitting end-diastolic volume index (EDVI), end-systolic volume index (ESVI), and stroke volume index over this age span. Peak cycle work rate declined with age similar to 40% in both sexes, but at any age it was greater in men than in women even after normalization for body weight. At peak effort, ejection fraction (EF), HR, and CI were reduced similarly with age while ESVI and TSVR were increased in both sexes; EDVI increased 35% with age and stroke work index (SWI) rose 19% in men, but neither was related to age in women; and stroke volume index did not vary with age in either sex. When hemodynamics were expressed as the change from rest to peak effort as an index of cardiovascular reserve function, both sexes demonstrated age-associated increases in EDVI and ESVI and reductions in EF, HR, and CI. However, the exercise-induced reduction in ESVI and the increases in EF, CI, and SWI from rest were greater in men than in women. Thus, age and gender each have a significant impact on the cardiac response to exhaustive upright cycle exercise.