Noninvasive measurement of cardiac output using partial CO/sub 2/ rebreathing
Noninvasive measurement of cardiac output using partial CO/sub 2/ rebreathing
复制标题
使用部分 CO/sub 2/再呼吸无创测量心输出量
DOI：
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发表时间：
1988
影响因子：
4.6
通讯作者：
R. Roy
中科院分区：
文献类型：
--
作者：
J. Capek;R. Roy
讨论了一种无创估计心输出量的算法。这项技术是基于正常通风时应用的CO/SUB2/FICK方程的微分形式和使用额外死区的30-S部分再呼吸期。使用微分形式的Fick方程消除了估计混合静脉PCo/sub2/的需要，而且心输出量估计值对肺泡死腔分数变化的敏感性大大降低。该程序是完全自动化的，需要最少的工作人员监督，每3又1/2分钟提供一次心输出量估计。心输出量的估计值与热稀释相比，相关系数为0.92，线性回归斜率为0.92(n=451)。肺泡死腔的暂时性增加并没有显著改变这种关系。与直接热稀释测量相比，在输注油酸引起的肺分流增加期间获得的心输出量估计值的相关系数为0.90，线性回归斜率为0.92。
A noninvasive algorithm for estimating cardiac output is discussed. The technique is based on a differential form of the CO/sub 2/ Fick equation applied during normal ventilation and a 30-s period of partial rebreathing using additional deadspace. Using the Fick equation in a differential form eliminates the need to estimate mixed venous pCO/sub 2/, also the sensitivity of the cardiac output estimate to changes in the alveolar deadspace fraction is greatly reduced. The procedure is fully automated, requires minimal staff supervision, and provides cardiac output estimates every 3 1/2-min. Estimates of cardiac output when compared to thermodilution yielded a correlation coefficient of 0.92 with a linear regression slope of 0.92 (n=451). Temporary increases in alveolar deadspace did not significantly alter this relationship. Cardiac output estimates obtained during period of increased pulmonary shunt due to oleic acid infusion yielded a correlation coefficient of 0.90 with a linear regression slope of 0.92 when compared to direct thermodilution measurements.<<ETX>>