Cold Stimuli on the Cheeks Activate the Left Ventrolateral Prefrontal Cortex and Enhance Cognitive Performance.
Cold Stimuli on the Cheeks Activate the Left Ventrolateral Prefrontal Cortex and Enhance Cognitive Performance.
复制标题
脸颊上的冷刺激会激活左腹外侧前额叶皮层并增强认知能力。
DOI：
10.1007/s41465-020-00192-2
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发表时间：
2021
影响因子：
2.2
通讯作者：
T Rikimaru
中科院分区：
文献类型：
--
作者：
Y Okura;T Rikimaru
大脑前额叶皮层（PFC）的激活在神经认知功能中起着重要的作用，如学习和认知表现。越来越多的人类研究使用近红外光谱（NIRS）广泛研究了与认知任务相关的PFC的激活。然而，冷刺激与神经认知功能和PFC激活的关联尚未使用NIRS阐明。我们研究了18名成年男性受试者的脸颊冷刺激对大脑PFC激活的影响。我们还研究了在有和没有冷刺激的Stroop认知测试中与PFC激活相关的认知表现的百分比变化。脸颊上的冷刺激显着增加血流双侧PFC，包括左背外侧区域。Stroop认知测试中认知能力的提高与冷刺激显著相关，这与PFC左背外侧区的激活增强相一致。因此，脸颊上的冷刺激可能导致Stroop认知能力的增强，冷刺激可以施加在脸颊上以通过以下方式改善认知表现：在日常生活中通过刺激三叉神经来增强PFC活动。此外，本研究的结果为使用冷刺激增强老年人认知能力的实用非药物干预提供了见解。
Activation of the cerebral prefrontal cortex (PFC) has been reported to play important roles in neurocognitive functions, such as learning and cognitive performance. An increasing number of human studies using near-infrared spectroscopy (NIRS) have extensively investigated the activation of the PFC associated with cognitive tasks. However, the association of cold stimulus with neurocognitive function and PFC activation has not been elucidated using NIRS. We examined the effect of cold stimulus on the cheeks on the activation of the cerebral PFC using NIRS in 18 adult male participants. We also examined the percent change in cognitive performance related to the activation of the PFC in the Stroop cognitive test with and without cold stimulus. Cold stimulus on the cheeks significantly increased blood flow bilaterally in the PFC, including the left dorsolateral regions. An increase in the cognitive performance on the Stroop cognitive test was significantly associated with the cold stimulus, which coincided with enhanced activation of the left dorsolateral region of the PFC. Therefore, cold stimulus on the cheeks may lead to enhanced Stroop cognitive performance, accompanied by the activation of the left dorsolateral region of the PFC. Cold stimuli may be applied on the cheeks to improve cognitive performance by enhancing the PFC activities via trigeminal nerve stimulation in the daily life. Furthermore, the findings of the present study provide insights for practical, non-pharmaceutical interventions using cold stimuli for cognitive enhancement in the elderly.