Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent
Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent
复制标题
DOI：
10.1002/ajh.21185
复制
发表时间：
2008-08-01
影响因子：
12.8
通讯作者：
Wolach, Baruch
中科院分区：
文献类型：
--
作者：
Berger-Achituv, Sivan;Ellis, Martin H.;Wolach, Baruch
输血相关急性肺损伤（TRALI）与所有含血浆的血液制品给药相关。我们报告一位14岁的青少年，诊断为特发性血小板减少性紫癜，在静脉注射抗D抗体后5小时内发生急性呼吸功能不全，与TRALI相容。9小时后发现完全非心源性肺水肿。不需要机械通气，患者在36小时后完全恢复。抗D制剂分析显示对中性粒细胞Fc γ RIIIb的反应性。输注后血清样本含有抗I类人HLA-A11抗原的抗体。临床医生应考虑TRALI在接受静脉抗D后发生不明原因呼吸困难的患者。
Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti-D preparation revealed reactivity against the neutrophil Fc gamma RIIIb. A postinfusion serum sample contained antibodies against class I human HLA-A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti-D.