The Race-Specific Incidence of Esophageal Squamous Cell Carcinoma in Individuals With Exposure to Tobacco and Alcohol.
The Race-Specific Incidence of Esophageal Squamous Cell Carcinoma in Individuals With Exposure to Tobacco and Alcohol.
复制标题
接触烟草和酒精的个体食管鳞状细胞癌的种族特异性发病率。
DOI：
10.1038/ajg.2016.346
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Rubenstein,JoelH
中科院分区：
文献类型：
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作者：
Prabhu,Anoop;Obi,Kenneth;Lieberman,David;Rubenstein,JoelH
目的：食管鳞状细胞癌（ESCC）在少数民族人群中的相对影响尚不完全清楚。我们的目的是估计ESCC的种族特异性发病率，并将其与患有胃食管反流病（GERD）的白人男性食管腺癌（EAC）的发病率联系起来。方法：从国家健康访谈调查中获得美国不同种族和性别的烟草和酒精暴露情况。ESCC暴露于烟草烟雾和/或酒精的标准化发病率是通过荟萃分析估计的。美国ESCC的现有发病率来自监测、流行病学和最终结果（SEER）项目。然后，我们利用这些数据建立了一个估计ESCC发病率的马尔可夫计算机模型。结果：与非西班牙裔白人、西班牙裔或亚洲人相比，SEER中ESCC的发生率在非洲裔美国人中最高。在我们的模型中，暴露于烟草和酒精的非裔美国男性ESCC的估计发病率接近每周发生GERD的非西班牙裔白人男性EAC的风险。例如，在60岁时，既吸烟又饮酒的非裔美国男性ESCC的发病率为30/100,000，而患有GERD的白人男性EAC的发病率为40/100,000。相比之下，在这个年龄段每周发生胃食管反流的非西班牙裔白人女性中，EAC的风险为6.2/100,000。结论：使用酒精和烟草的非裔美国男性ESCC发病率最高，与其他筛查疾病相当。应考虑在高危人群中制定ESCC的筛查和预防方案。
Objectives:The relative impact of esophageal squamous cell carcinoma (ESCC) in minority populations is incompletely understood. We aimed to estimate the race-specific incidences of ESCC and place these in the context of the incidence of esophageal adenocarcinoma (EAC) in white men with gastroesophageal reflux disease (GERD).Methods:The race-and sex-specific exposures to tobacco and alcohol in the United States were obtained from the National Health Interview Survey. The standardized incidence ratios of exposure to tobacco smoke and/or alcohol for ESCC were estimated from meta-analyses. Existing incidences of ESCC in the United States were obtained from the Surveillance, Epidemiology, and End Results (SEER) program. We then used this data to inform a Markov computer model estimating the incidence of ESCC.Results:The incidence of ESCC reported in SEER was the greatest among African-Americans compared with white non-Hispanics, Hispanics, or Asians. In our model, the estimated incidence of ESCC in African-American men exposed to tobacco and alcohol approached the risk of EAC in white non-Hispanic men with weekly GERD. For instance, at age 60 years, the incidence of ESCC in African-American men who have used both tobacco and alcohol was 30/100,000 compared with an incidence of EAC in white men with GERD of 40/100,000. In comparison, the risk of EAC in white non-Hispanic women with weekly GERD at this age was 6.2/100,000.Conclusions:The incidence of ESCC in African-American men who use alcohol and tobacco is the highest and comparable to other screened diseases. Development of screening and prevention programs for ESCC in high-risk populations should be considered.