A meta-analysis of impact of proton pump inhibitors on antiplatelet effect of clopidogrel.
A meta-analysis of impact of proton pump inhibitors on antiplatelet effect of clopidogrel.
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DOI：
10.1111/j.1755-5922.2011.00304.x
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发表时间：
2012-12
影响因子：
3.1
通讯作者：
Rabi Yacoub
中科院分区：
文献类型：
--
作者：
Rabi Yacoub
. [1] evaluatingthe impact of proton pump inhibitors (PPIs) on antiplatelet effectof clopidogrel by conducting a meta-analysis of comparative con-comitant use of clopidogrel with PPIs versus clopidogrel withoutPPIs, with the endpoint being cardiovascular events. The authorsconducted a comprehensive search using multiple databases.Thirteenarticleswereincludedintheirarticleandonlysevenwereanalyzed in the final module. Heterogeneity was found across thestudy and they concluded that there is an obvious discrepancy be-tween the randomized control trials (RCTs) and the observationaltrials studied, and recommended large-scale RCTs to ascertain thetrue effects of PPIs on clopidogrel with respect to cardiovascularevents.Careful review of this interesting article reveals many weak-nesses and flaws.1. Search criteria and articles included in their final analysis: Noobvious inclusion and exclusion criteria were described in thestudy. It is unclear why they evaluated only seven articles outof the 13 articles they found through their search. A re-cent meta-analysis conducted by Siller-Matula
