Psychopathology in Huntington's disease patients
Psychopathology in Huntington's disease patients
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亨廷顿病患者的精神病理学
DOI：
10.1111/j.1600-0447.1994.tb01587.x
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发表时间：
1994
影响因子：
6.7
通讯作者：
R. Shiwach
中科院分区：
文献类型：
--
作者：
R. Shiwach
一项对地区遗传中心已知的30个亨廷顿病家族（110名患者：75名存活，35名死亡）的回顾性研究，使用多种信息来源，显示抑郁症在前驱症状和疾病诊断阶段的最低终生患病率为39%。有症状的精神分裂症的发生率约为9%，在72%的样本中发现了显着的性格变化，其中一些导致了严重的行为异常。这些发现强化了这样一个观点，即抑郁症和精神分裂症，如果没有伴随或之前有器质性人格变化和/或非常早期的神经症状，不太可能导致疾病的最终表现。
A retrospective study of 30 Huntington's disease families (110 patients: 75 alive and 35 dead) known to a regional genetic centre, using multiple sources of information, showed the minimum lifetime prevalence of depression to be 39% in the prodrome and the diagnosed disease phase of the illness. The frequency of symptomatic schizophrenia was found to be about 9% and significant personality changes were found in 72% of the sample, some of them leading to gross behavioural anomalies. The findings reinforce the point that depression and schizophrenia, unaccompanied or preceded by organic personality changes and/or very early neural symptoms, are unlikely to lead to the eventual manifestation of the disease.
影响因子：
--
作者：
Thompson,WD;Orvaschel,H;Prusoff,BA;Kidd,KK
通讯作者：
Kidd,KK