Alcohol, wine, and health
Alcohol, wine, and health
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DOI：
10.1016/s0002-9610(00)00486-4
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发表时间：
2000-11-01
影响因子：
3
通讯作者：
de Lorimier, AA
中科院分区：
文献类型：
--
作者：
de Lorimier, AA
背景技术背景：在过去的20年里，大量的流行病学研究已经将饮酒与各种疾病状态联系起来：总死亡率、动脉血管疾病、高血压、癌症、消化性溃疡、呼吸道感染、胆结石、肾结石、年龄相关性黄斑变性、骨密度和认知功能。对这些文章的回顾表明，这些研究中的每一项都比较了不同饮酒水平的个体与戒酒者的结果。结果：每个分析都确定了一个U形或J形曲线，与戒酒者相比，给定的疾病状态的相对风险降低。一个明确的定义，消费量在适度变得明显：对于男性来说，它不应该超过2至4饮料，每天，和女性不应该超过1至2饮料，每天.CONCLUSIONS：酒精本身具有良好的影响，对高密度脂蛋白胆固醇的水平，抑制血小板聚集。葡萄酒，特别是红葡萄酒，具有高水平的酚类化合物，这些酚类化合物有利地影响多种生化系统，例如增加高密度脂蛋白胆固醇、抗氧化活性、降低血小板聚集和内皮粘附、抑制癌细胞生长和促进一氧化氮产生。Am J Surg. 2000;180：357-361，（C）2000，Excerpta Medica，Inc.
BACKGROUND: For the past 20 years numerous epidemiological studies have correlated the consumption of alcohol and a variety of disease states: overall mortality, arteriosclerotic vascular diseases, hypertension, cancers, peptic ulcer, respiratory infections, gall stones, kidney stones, age-related macular degeneration, bone density, and cognitive function.METHODS: A review of these articles reveals that each of these studies has compared the outcome of individuals at various levels of alcohol consumption with that of abstainers.RESULTS: Each analysis has identified a U-shaped or J-shaped curve of reduced relative risk for a given disease state compared with abstainers. A clear definition of consumption in moderation becomes evident: for men it should not exceed 2 to 4 drinks per day, and for women it should not exceed 1 to 2 drinks per day.CONCLUSIONS: Alcohol by itself has favorable effects on the level of high-density lipoprotein cholesterol, and inhibition of platelet aggregation. Wine, particularly red wine, has high levels of phenolic compounds that favorably influence multiple biochemical systems, such as increased high-density lipoprotein cholesterol, antioxidant activity, decreased platelet aggregation and endothelial adhesion, suppression of cancer cell growth, and promotion of nitric oxide production. Am J Surg. 2000;180:357-361, (C) 2000 by Excerpta Medica, Inc.