Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients
Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients
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DOI：
10.1046/j.1365-2222.1998.00399.x
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发表时间：
1998-11-01
影响因子：
6.1
通讯作者：
Asero, R
中科院分区：
文献类型：
--
作者：
Asero, R
背景大多数桦树花粉过敏患者在食用新鲜苹果和其他蔬菜食物后报告口腔过敏症状。桦树花粉和苹果花粉的主要变应原Betv 1和Mald 1高度同源;结果，目的探讨桦树花粉特异性免疫治疗（SIT）对苹果致口腔变态反应综合征（OAS）的临床疗效和免疫学效果。诱导OAS，接受注射免疫治疗12、24或36个月。26例未接受SIT的患者随访12-48个月作为对照。结果41例患者（84%）在SIT治疗后OAS症状明显减轻（50-95%）或完全消失（100%），对照组（0%）无明显变化（P > 0.05）。
Background Most patients with birch pollen allergy report oral allergy symptoms after eating fresh apples and other vegetable foods. Major birch pollen and apple allergens, Bet v 1 and Mal d 1, are highly homologous; as a consequence, pollen-specific immunotherapy (SIT) might be expected to improve apple hypersensitivity.Objective To evaluate the clinical and immunological effects of birch pollen SIT on oral allergy syndrome (OAS) induced by apples.Methods A prospective study carried out in 49 birch pollen-sensitive patients with apple-induced OAS who received injection immunotherapy for 12, 24, or 36 months. Twenty-six patients not submitted to SIT and followed up for 12-48 months were used as controls. Both SPT and open oral challenges with fresh golden delicious apple were performed, as well as specific IgE measurements, before and after SIT.Results Forty-one patients (84%) vs no control (0%) reported a significant reduction (50-95%) or a total disappearance (100%) of OAS symptoms after SIT (P