Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release.
Role of amygdala in mediating sexual and emotional behavior via coupled nitric oxide release.
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杏仁核通过耦合一氧化氮释放调节性行为和情绪行为的作用。
DOI：
10.1111/j.1745-7254.2005.00083.x
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Stefano,GeorgeB
中科院分区：
文献类型：
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作者：
Salamon,Elliott;Esch,Tobias;Stefano,GeorgeB
尽管人们对杏仁核的解剖结构进行了大量的研究，但对这一情绪调节中心控制情绪和性行为的确切机制的研究却很少。通过应用神经科学研究所，纽约州立大学，老韦斯特伯里学院的研究方法，我们打算证明杏仁核的许多介导作用，特别是对男性和女性性反应周期的调节，以及相关的情绪考虑，发挥其与一氧化氮（NO）释放相结合的作用。此外，通过使用现有的解剖和组织学数据，我们证明了杏仁核组织富含内源性大麻素和阿片，以及儿茶酚胺，受体可以在no介导的范式中发挥其神经化学作用。这一范式，连同杏仁核中存在的雌激素和雄激素信号，进一步为我们的理论框架提供了可信度。我们首先简要回顾杏仁核的解剖和功能，然后进一步证明其与一氧化氮的关系。
Although the anatomical configuration of the amygdala has been studied a great deal, very little research has been conducted on understanding the precise mechanism by which this emotional regulatory center exerts its control on emotional and sexual behavior. By applying research methodology from the Neuroscience Research Institute, State University of New York, College at Old Westbury, we intended to demonstrate that much of the mediated effects of the amygdala, specifically the regulation of the male and female sexual response cycles, as well as related emotional considerations, exert their effects coupled to nitric oxide (NO) release. Furthermore, by using current anatomical and histological data, we demonstrated that amygdalar tissue rich in endocannabinoid and opiate, as well as catecholamine, receptors could exert its neurochemical effects within an NO-mediated paradigm. This paradigm, together with the existence of estrogen and androgen signaling within the amygdala, further lends credence to our theoretical framework. We begin with a brief anatomical and functional review of amygdalar function, and then proceed to demonstrate its relationship with NO.