The coaction of tonic and phasic dopamine dynamics.

The coaction of tonic and phasic dopamine dynamics.
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DOI:
10.1039/c4cc06165a
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发表时间:
2015-02-11
期刊:
Chemical communications (Cambridge, England)
影响因子:
--
通讯作者:
Heien ML
Heien ML
中科院分区:
其他
文献类型:
--
作者:
Atcherley CW;Wood KM;Parent KL;Hashemi P;Heien ML

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强直性神经化学物质多巴胺活动是许多大脑功能的基础;但是,尚未就这一重要的集中达成协商一致意见。在这项工作中,我们引入体内快速扫描控制吸附伏安法来报告小鼠大脑中的多巴胺浓度(90±9 nM)和多巴胺扩散系数(1.05±0.09 ×10−6 cm2/s)。
Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 ×10−6 cm2/s) in the mouse brain.