Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
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DOI：
10.1016/j.neulet.2012.01.017
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发表时间：
2012-02-29
影响因子：
2.5
通讯作者：
Wahlund, L. O.
中科院分区：
文献类型：
--
作者：
Besga, A.;Cedazo-Minguez, A.;Wahlund, L. O.
在两组有记忆障碍且脑脊液Aβ42和脑脊液tau水平不同的患者中，研究脑白质高信号(WMH)与胆固醇和胰岛素代谢的可能联系。来自卡罗林斯卡医院记忆诊所的59名患者包括在内。使用ARWMC量表对WMHs的程度进行分级，并测量脑脊液和血浆中的下列生物标志物：胰岛素、胆固醇、羊毛甾醇、催产素和氧化胆固醇代谢物。脑脊液对照组的WMHs与脑胆固醇合成增加、脑脊液中氧化甾醇和胰岛素外流减少相关。在脑脊液类AD组，WMHs与外周胆固醇代谢增加相关。尽管在FLAIR图像上有相似的外观，但在被调查的两组中，WMH的致病机制可能不同。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Investigate possible associations of white matter hyperintensities (WMHs) with the metabolism of cholesterol and insulin in two subgroups of patients with memory complaints and different CSF A beta 42 and CSF tau levels. 59 patients from the memory clinic at Karolinska Hospital were included. Degree of WMHs was rated using the ARWMC scale and the following biomarkers were measured in CSF and plasma: insulin, cholesterol, lanosterol, lathosterol, and oxidized cholesterol metabolites. The WMHs in CSF control-like group correlated with increased brain cholesterol synthesis and reduced efflux of oxysterols and insulin in CSF. In the CSF AD-like group, the WMHs correlated with increased peripheral cholesterol metabolism. Despite having similar appearance on FLAIR images, the pathogenic mechanisms of WMHS are likely to be different in the two groups investigated. (C) 2012 Elsevier Ireland Ltd. All rights reserved.