The HSC niche concept has turned 31. Has our knowledge matured?
The HSC niche concept has turned 31. Has our knowledge matured?
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DOI：
10.1111/j.1749-6632.2009.05223.x
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发表时间：
2010-03
影响因子：
5.2
通讯作者：
Scadden DT
中科院分区：
文献类型：
--
作者：
Lymperi S;Ferraro F;Scadden DT
造血干细胞(HSC)生态位目前被定义为骨髓(BM)中特定的微环境，从解剖学上讲，它容纳并控制着HSC的命运。它在调节HSCs的存活和自我更新能力、保护其免于衰竭的同时防止其过度增殖方面起着关键作用。许多不同类型的基质细胞被认为是生态位的组成部分，但它们的整合功能仍未被揭示。干细胞/祖细胞行为在生态位中的调节机制包括细胞与细胞之间的相互作用以及生长因子、细胞因子和细胞外基质蛋白的产生。HSC生态位是一个反映和响应有机体需求的动态实体。了解利基如何参与维持组织的动态平衡和修复，为开发新的治疗工具提供了新的机会。
The hematopoietic stem cell (HSC) niche is currently defined as the specific microenvironment in the bone marrow (BM) which anatomically harbors HSCs and governs their fate. It plays a pivotal role in regulating the survival and self-renewal ability of HSCs, protecting them from exhaustion while preventing their excessive proliferation. Many different stromal cell types have been proposed as putative constituents of the niche, but their integrated function is still unrevealed. Mechanisms by which stem/progenitor cell behavior is regulated in the niche include cell-to-cell interaction and the production of growth factors, cytokines, and extracellular matrix proteins. The HSC niche is a dynamic entity reflecting and responding to the needs of the organism. An understanding of how the niche participates in the maintenance of tissue homeostasis and repair offers new opportunities for the development of novel therapeutic tools.
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影响因子：
64.8
作者：
Adams, Gregor B.;Alley, Ian R.;Chung, Ung-il;Chabner, Karissa T.;Jeanson, Nathaniel T.;Lo Celso, Cristina;Marsters, Emily S.;Chen, Min;Weinstein, Lee S.;Lin, Charles P.;Kronenberg, Henry M.;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
64.5
作者：
Kiel, MJ;Yilmaz, ÖH;Morrison, SJ
通讯作者：
Morrison, SJ
影响因子：
64.5
作者：
Sacchetti, Benedetto;Funari, Alessia;Bianco, Paolo
通讯作者：
Bianco, Paolo
影响因子：
82.9
作者：
Kollet, Orit;Dar, Ayelet;Lapidot, Tsvee
通讯作者：
Lapidot, Tsvee
影响因子：
20.3
作者：
Flynn, Catherine M.;Kaufman, Dan S.
通讯作者：
Kaufman, Dan S.