EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING
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DOI：
10.1148/radiology.182.2.1732968
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发表时间：
1992-02-01
期刊：
影响因子：
19.7
通讯作者：
COHEN, JA
中科院分区：
文献类型：
--
作者：
DOUSSET, V;GROSSMAN, RI;COHEN, JA
磁化传递成像（MTI）最初在正常豚鼠和人类志愿者中进行。 在正常白色物质中计算磁化传递率（MTR），发现其为42%-44%，变化小于2.5%，这表明测量的高再现性。 然后将MTI应用于白色疾病、急性实验性变态反应性脑脊髓炎（EAE）的动物模型。 在该EAE模型中，病理证实的病变是水肿的，基本上没有脱髓鞘。 与病变发生前测量的相同组织区域的MTR相比，MTR略有增加但显著增加（6%-7%）。 15例多发性硬化（MS）患者也接受了MTI。 在15例MS患者中，所有病变（209个斑块）的MTR均显著降低（平均26%）。 作者认为，脱髓鞘导致MTR降低，因此，根据髓鞘丢失的程度，病变的转移率不同。 在MS患者中，特别是慢性和/或进展性MS患者，正常外观的白色物质的MTR显著降低。 这些数据表明，在体内MTI获得的计算MTR可以区分水肿和脱髓鞘，并且MTI可以显示标准自旋回波或梯度回波磁共振成像无法看到的白色物质异常。
Magnetization transfer imaging (MTI) was initially performed in normal guinea pigs and human volunteers. A magnetization transfer ratio (MTR) was calculated in the normal white matter and was found to be 42%-44%, with less than 2.5% variation, which indicates the high reproducibility of the measurement. MTI was then applied to an animal model of white matter disease, acute experimental allergic encephalomyelitis (EAE). In this model of EAE, pathologically proved lesions were edematous with essentially no demyelination. MTRs increased slightly but significantly (6%-7%) compared with the MTRs of the same tissue region measured before the onset of the lesion. Fifteen patients with multiple sclerosis (MS) also underwent MTI. In the 15 patients with MS, all lesions (209 plaques) had a significantly decreased MTR (average, 26%). The authors believe that demyelination produced the lower MTR, and, thus, lesions varied in transfer ratio on the basis of the extent of myelin loss. In patients with MS, particularly those with chronic and/or progressive MS, the MTR of the normal-appearing white matter was significantly decreased. The data suggest that calculated MTR obtained with in vivo MTI may enable differentiation of edema from demyelination, and that MTI can demonstrate white matter abnormalities that cannot be seen with standard spin-echo or gradient-echo magnetic resonance imaging.