Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study.
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study.
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DOI：
10.1038/s41598-021-93846-w
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发表时间：
2021-07-19
影响因子：
4.6
通讯作者：
Wibowo N
中科院分区：
文献类型：
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作者：
Irwinda R;Hiksas R;Siregar AA;Saroyo YB;Wibowo N
长链多不饱和脂肪酸（LCPUFA）在整个怀孕期间是必不可少的，因为LPUFA的缺乏可能与产科并发症有关。本研究旨在探讨LCPUFA在重度子痫前期和早产中的地位。对104名孕妇进行了横断面研究，分为正常妊娠组、重度先兆子痫组和早产组。采用气相色谱/质谱法测定血清总LCPUFA、omega-3、α -亚麻酸（ALA）、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）、omega-6、亚油酸（LA）和花生四烯酸（AA）的百分比和浓度。进行受试者工作特征（ROC）、双变量和多变量分析。重度子痫前期患者总PUFA浓度最高，DHA百分比最低，Omega-6/Omega-3比值显著高于对照组（p = 0.004）， Omega-3指数显著低于对照组（p < 0.002）。与对照组相比，早产儿omega-3浓度最低，omega-6衍生物(LA （p = 0.014）和AA （p = 0.025）明显较低。LCPUFA参数显示两种情况下的风险增加，特别是ALA≤53 μ mol/L子痫前期的OR为5.44,95%CI为1.16-25.42，早产的OR为4.68,95%CI为1.52-14.38。这些发现表明严重的子痫前期和早产在LCPUFA状态上存在不平衡。
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status.