ANDROGEN AND ESTROGEN METABOLISM - RELATIONSHIP TO OBESITY
ANDROGEN AND ESTROGEN METABOLISM - RELATIONSHIP TO OBESITY
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DOI：
10.1016/0026-0495(86)90206-4
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发表时间：
1986-03-01
影响因子：
9.8
通讯作者：
JOHNSTON, CC
中科院分区：
文献类型：
--
作者：
LONGCOPE, C;BAKER, R;JOHNSTON, CC
脂肪组织含有芳香化酶和17 - β。-类固醇脱氢酶活性。因此，为了了解肥胖与雄激素和雌激素代谢的某些参数是否存在关系，我们注射了88名女性，平均年龄为51.1 .+-。0.3岁，平均体重140 +-。3磅，注射3h -睾酮(T)/ 14c -雌二醇（E2）和3h -雄烯二酮4天后。检测血液中A、T、E1、E2和二氢睾酮（DHT）的放射性，检测尿液中E1和E2的放射性。根据这些数据，我们计算出A转化为T的百分比。[.]BBA,T =输入A的百分比（以血液中T为单位），[.rho.][.rho],该剧。BBE1，E2和[.rho.]BBE2,E1。我们还测量了在雄激素输注期间3H-DHT的放射性与3H-A （CRA，DHT）和3H-T （CRT，DHT）的放射性之比。根据3H-A或3H-T输注后尿液中3H/14C作为雌酮或雌二醇的比例，我们计算出A或T芳香化为E1或E2的百分比（[.rho.]BMAE1）；[.rho] BMT E2)。当这些妇女的数据与体重或血小板指数（QI = wt/ht2）相关时，与体重和QI显著相关的值只有[rho]BMT，E2和[.rho.]BMA,E1；对于所有其他的[.rho.]]和CR值与体重或QI无关。我们得出结论外周芳构化与肥胖呈正相关，但雄激素相互转化与肥胖无关，雄激素相互转化和雌激素相互转化与肥胖无关。
Adipose tissue contains both aromatase and 17.beta.-steroid dehydrogenase activity. Therefore, to see whether there was a relationship between obesity and certain parameters of androgen and estrogen metabolism we infused 88 women, mean age and 51.1 .+-. 0.3 years and mean weight 140 .+-. 3 lbs, with 3H-testosterone (T)/14C-estradiol (E2) and 3H-androstenedione 4 days following the start of the infusion. The blood samples were analyzed for radioactivity as A, T, E1, E2, and dihydrotestosterone (DHT) and the urines were analyzed for radioactivity as E1 and E2. From these data we calculated the percent of A converted to T ([.rho.]BBA,T = percent of A infused measured as T in the blood), [.rho.]BBT,A [.rho.]BBE1,E2, and [.rho.]BBE2,E1. We also measured the ratio of radioactivity as 3H-DHT to radioactivity as 3H-A (CRA,DHT) and 3H-T (CRT,DHT) during the respective androgen infusions. From the ratio of 3H/14C as estrone or estradiol in the urine following 3H-A or 3H-T infusions, we calculated the percent of A or T that was aromatized to E1 or E2 ([.rho.]BMAE1); [.rho.]BMT,E2). When the data from these women were related to weight or Quetelets Index (QI = wt/ht2) by unweighted linear regression, the only values that were significantly correlated with weight and QI were [rrho]BMT,E2 and [.rho.]BMA,E1; for all other [.rho.] and CR values there was no correlation with weight or QI. We conclude that peripheral aromatization is positively correlated with adiposity but androgen interconversion but androgen interconversions and estrogen interconversions are not related to adiposity.