An inside job for siRNAs.
An inside job for siRNAs.
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DOI:
10.1016/j.molcel.2008.07.008
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发表时间:
2008-08-08
期刊:
影响因子:
16
通讯作者:
Sontheimer, Erik J.
中科院分区:
文献类型:
--
作者:
Golden, Daniel E.;Gerbasi, Vincent R.;Sontheimer, Erik J.
Among the three main categories of small silencing RNAs in insects and mammals—siRNAs, miRNAs, and piRNAs—siRNAs were thought to arise primarily from exogenous sources, whereas miRNAs and piRNAs arise from endogenous loci. Recent work in flies and mice reveals several classes of endogenous siRNAs (endo-siRNAs) that contribute to functions previously reserved for miRNAs and piRNAs, including gene regulation and transposon suppression.
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