Boronate Ester Bullvalenes
Boronate Ester Bullvalenes
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DOI：
10.1021/jacs.9b12930
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发表时间：
2020-02-26
影响因子：
15
通讯作者：
Fallon, Thomas
中科院分区：
文献类型：
--
作者：
Patel, Harshal D.;Thanh-Huyen Tran;Fallon, Thomas
现在只需两到四个操作简单的步骤就可以获得硼酸酯牛皮烯。这通过铃木交叉偶联反应释放了后期的多样化，得到了单取代、双取代和三取代的牛皮烯。此外，关键策略允许预先编程安装两个不同的取代基。对溶液相异构体分布和单晶X射线结构的分析表明，异构体在晶格中的择优是由于一般的形状选择性。
Boronate ester bullvalenes are now accessible in two to four operationally simple steps. This unlocks late-stage diversification through Suzuki cross-coupling reactions to give mono-, di-, and trisubstituted bullvalenes. Moreover, a linchpin strategy enables preprogrammed installation of two different substituents. Analysis of solution phase isomer distributions and single crystal X-ray structures reveals that isomer preference in the crystal lattice is due to general shape selectivity.