Paediatric tuberculosis.
Paediatric tuberculosis.
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DOI：
10.1016/s1473-3099(08)70182-8
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发表时间：
2008-08
影响因子：
56.3
通讯作者：
Kampmann, Beate
中科院分区：
文献类型：
--
作者：
Newton, Sandra M.;Brent, Andrew J.;Anderson, Suzanne;Whittaker, Elizabeth;Kampmann, Beate
在全球范围内，结核病继续在儿童中造成令人无法接受的高疾病和死亡人数，特别是在艾滋病毒流行之后。国际旅行和移民的增加使儿童结核病发病率增加，即使在传统上负担较低的工业化环境中也是如此，并有可能促进多药耐药菌株的出现和传播。虽然对新的诊断、治疗和预防干预措施的密集科学和临床研究工作集中在成人结核病上，但儿童结核病相对被忽视。然而，儿童特别容易感染严重疾病和感染后死亡，那些潜伏感染的人在成年后成为疾病重新激活的蓄水池，助长了未来的流行病。迫切需要进一步研究儿童结核病的流行病学、免疫机制、诊断、治疗和预防。我们对儿童结核病的了解的进步将提供更广泛的见解和机会，以促进控制这一古老疾病的努力。
Globally, tuberculosis (TB) continues to exact an unacceptably high toll of disease and death among children, particularly in the wake of the HIV epidemic. Increased international travel and immigration have seen childhood TB rates increase even in traditionally low burden, industrialised settings, and threaten to facilitate the emergence and spread of multi-drug resistant strains. While intense scientific and clinical research efforts into novel diagnostic, therapeutic and preventative interventions have focused on TB in adults, childhood TB has been relatively neglected. However, children are particularly vulnerable to severe disease and death following infection, and those with latent infection become the reservoir of disease reactivation in adulthood, fueling the future epidemic. Further research into the epidemiology, immune mechanisms, diagnosis, treatment and prevention of childhood TB is urgently needed. Advances in our understanding of TB in children would provide wider insights and opportunities to facilitate efforts to control this ancient disease.