Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene.
Molecular lesions in alleles of the Caenorhabditis elegans lin-11 gene.
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DOI：
10.17912/micropub.biology.000589
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发表时间：
2022
影响因子：
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通讯作者：
Sundaram, Meera V
中科院分区：
文献类型：
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作者：
Young, Adrie F;Schmidt, Helen F;Sundaram, Meera V
LIM 同源域转录因子 LIN-11 是线虫外阴、子宫和神经元发育的关键调节因子。 lin-11 的多个等位基因可用，但尚未测序。我们发现参考等位基因 n389 是一个 15900 bp 的缺失，它也影响另外两个蛋白质编码基因 ZC247.1 和 ZC247.2。常用的 n566 等位基因是位于内含子中的 288bp 缺失，影响剪接受体位点。
The LIM homeodomain transcription factor LIN-11 is a key regulator of vulva, uterine, and neuron development in C. elegans. Multiple alleles of lin-11 are available, but none had been sequenced. We found that the reference allele, n389, is a 15900 bp deletion that also affects two other protein-coding genes, ZC247.1 and ZC247.2. The frequently used n566 allele is a 288bp deletion located in an intron and affecting the splice acceptor site.